A roadmap for the human developmental cell atlas
Abstract The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …
[HTML][HTML] Cell fate decisions, transcription factors and signaling during early retinal development
R Diacou, P Nandigrami, A Fiser, W Liu… - Progress in retinal and …, 2022 - Elsevier
The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …
[PDF][PDF] Cell types of the human retina and its organoids at single-cell resolution
CS Cowan, M Renner, M De Gennaro, B Gross-Scherf… - Cell, 2020 - cell.com
Human organoids recapitulating the cell-type diversity and function of their target organ are
valuable for basic and translational research. We developed light-sensitive human retinal …
valuable for basic and translational research. We developed light-sensitive human retinal …
[PDF][PDF] Human brain organoids assemble functionally integrated bilateral optic vesicles
E Gabriel, W Albanna, G Pasquini, A Ramani… - Cell Stem Cell, 2021 - cell.com
During embryogenesis, optic vesicles develop from the diencephalon via a multistep
process of organogenesis. Using induced pluripotent stem cell (iPSC)-derived human brain …
process of organogenesis. Using induced pluripotent stem cell (iPSC)-derived human brain …
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression
J Liu, D Ottaviani, M Sefta, C Desbrousses… - Nature …, 2021 - nature.com
Retinoblastoma is the most frequent intraocular malignancy in children, originating from a
maturing cone precursor in the developing retina. Little is known on the molecular basis …
maturing cone precursor in the developing retina. Little is known on the molecular basis …
[PDF][PDF] The single-cell and spatial transcriptional landscape of human gastrulation and early brain development
B Zeng, Z Liu, Y Lu, S Zhong, S Qin, L Huang, Y Zeng… - Cell Stem Cell, 2023 - cell.com
The emergence of the three germ layers and the lineage-specific precursor cells
orchestrating organogenesis represent fundamental milestones during early embryonic …
orchestrating organogenesis represent fundamental milestones during early embryonic …
[PDF][PDF] Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition
We previously used single-cell transcriptomic analysis to characterize human fetal retinal
development and assessed the degree to which retinal organoids recapitulate normal …
development and assessed the degree to which retinal organoids recapitulate normal …
Retinoblastoma from human stem cell-derived retinal organoids
Retinoblastoma is a childhood cancer of the developing retina that initiates with biallelic
inactivation of the RB1 gene. Children with germline mutations in RB1 have a high …
inactivation of the RB1 gene. Children with germline mutations in RB1 have a high …
[PDF][PDF] Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina
Gene regulatory networks (GRNs), consisting of transcription factors and their target sites,
control neurogenesis and cell-fate specification in the developing central nervous system. In …
control neurogenesis and cell-fate specification in the developing central nervous system. In …
A lamprey neural cell type atlas illuminates the origins of the vertebrate brain
F Lamanna, F Hervas-Sotomayor, AP Oel… - Nature Ecology & …, 2023 - nature.com
The vertebrate brain emerged more than~ 500 million years ago in common evolutionary
ancestors. To systematically trace its cellular and molecular origins, we established a …
ancestors. To systematically trace its cellular and molecular origins, we established a …