AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Mast cells and their mediators have been implicated in the pathogenesis of asthma and
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …

Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common
neurodevelopmental disorders having a high influence on social interactions. The number of …

Neurodegenerative diseases represent nowadays one of the major health problems.
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not …

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder of unknown etiology.
IBS is caused by a disruption in the gut-brain axis. Given the importance of the gut …

Histamine has been one of the most studied substances in medicine, playing a major role in
diverse (patho) physiological processes. It elicits its multifaceted modulatory functions by …

The histamine receptors belong to the G protein-coupled receptor (GPCR) superfamily, and
play important roles in the regulation of histamine and other neurotransmitters in the central …

Within the gastrointestinal tract, histamine is present at relatively high concentrations,
especially during inflammatory processes. Histamine is a biogenic amine with numerous …

Histamine plays pleiotropic roles as a neurotransmitter in the physiology of brain function,
this includes the maintenance of wakefulness, appetite regulation and memory retrieval …