Fibrotic diseases are characterised by myofibroblast differentiation, uncontrolled
pathological extracellular matrix accumulation, tissue contraction, scar formation and …

Scars occur as a result of fibrosis after tissue damage or surgery and reports suggest that
excessive Transforming growth factor-β (TGF-β) activity during the process of wound healing …

During in vitro culture, bereft of their optimal tissue context, tenocytes lose their phenotype
and function. Considering that tenocytes in their native tissue milieu are exposed …

Macromolecular crowding (MMC) enhances and accelerates extracellular matrix (ECM)
deposition in eukaryotic cell culture. Single hyaluronic acid (HA) molecules have not …

The use of macromolecular crowding in the development of extracellular matrix-rich cell-
assembled tissue equivalents is continuously gaining pace in regenerative engineering …

Single molecule drug delivery systems have failed to yield functional therapeutic outcomes,
triggering investigations into multi-molecular drug delivery vehicles. In the context of skin …

Modern bioengineering utilises biomimetic cell culture approaches to control cell fate during
in vitro expansion. In this spirit, herein we assessed the influence of bidirectional surface …

Skin fibrosis still constitutes an unmet clinical need. Although pharmacological strategies are
at the forefront of scientific and technological research and innovation, their clinical …

Although cell-derived matrices are at the forefront of scientific research and technological
innovation for the development of in vitro tumour models, their two-dimensional structure …

The absence of a native extracellular matrix and the use of xenogeneic sera are often
associated with rapid tenocyte function losses during in vitro culture. Herein, we assessed …