Advances and impact of arginine-based materials in wound healing
In studies on wound-dressing materials, bioactive materials have been developed rapidly to
accelerate wound healing. In recent years, scientists have studied arginine as a bioactive …
accelerate wound healing. In recent years, scientists have studied arginine as a bioactive …
Arginine and arginine-rich peptides as modulators of protein aggregation and cytotoxicity associated with Alzheimer's disease
A substantial body of evidence indicates cationic, arginine-rich peptides (CARPs) are
effective therapeutic compounds for a range of neurodegenerative pathologies, with …
effective therapeutic compounds for a range of neurodegenerative pathologies, with …
Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for …
S Zhong, Y Lian, W Luo, R Luo, X Wu, J Ji, Y Ji… - Acta …, 2021 - Springer
Neuronal intranuclear inclusion disease (NIID) is neurodegenerative disease characterized
by widespread inclusions. Despite the identification of GGC repeat expansion in 5'UTR of …
by widespread inclusions. Despite the identification of GGC repeat expansion in 5'UTR of …
Polyglutamine disorders: Pathogenesis and potential drug interventions
S Tandon, P Aggarwal, S Sarkar - Life Sciences, 2024 - Elsevier
Polyglutamine/poly (Q) diseases are a group nine hereditary neurodegenerative disorders
caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct …
caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct …
Protein aggregation inhibitors as disease-modifying therapies for polyglutamine diseases
EN Minakawa, Y Nagai - Frontiers in neuroscience, 2021 - frontiersin.org
The polyglutamine (polyQ) diseases are a group of inherited neurodegenerative diseases
caused by the abnormal expansion of a CAG trinucleotide repeat that are translated into an …
caused by the abnormal expansion of a CAG trinucleotide repeat that are translated into an …
CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease
Huntington's disease (HD) is a hereditary neurodegenerative disorder of the basal ganglia
for which disease-modifying treatments are not yet available. Although gene-silencing …
for which disease-modifying treatments are not yet available. Although gene-silencing …
The molecular pathogenesis of repeat expansion diseases
Y Fujino, Y Nagai - Biochemical Society Transactions, 2022 - portlandpress.com
Expanded short tandem repeats in the genome cause various monogenic diseases,
particularly neurological disorders. Since the discovery of a CGG repeat expansion in the …
particularly neurological disorders. Since the discovery of a CGG repeat expansion in the …
Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease
ID Gaudet, H Xu, E Gordon, GA Cannestro… - Journal of …, 2024 - Springer
We previously identified solute carrier family 7 member 2 (SLC7A2) as one of the top
upregulated genes when normal Huntingtin was deleted. SLC7A2 has a high affinity for l …
upregulated genes when normal Huntingtin was deleted. SLC7A2 has a high affinity for l …
Mechanism underlying liquid-to-solid phase transition in fused in sarcoma liquid droplets
S Li, T Yoshizawa, Y Shiramasa… - Physical Chemistry …, 2022 - pubs.rsc.org
The RNA-binding protein fused in sarcoma (FUS) forms ribonucleoprotein granules via
liquid–liquid phase separation (LLPS) in the cytoplasm. The phase separation of FUS …
liquid–liquid phase separation (LLPS) in the cytoplasm. The phase separation of FUS …
Metabolic deregulation associated with aging modulates protein aggregation in the yeast model of Huntington's disease
SS Pradhan, SP Kanikaram, DD VM… - Journal of …, 2023 - Taylor & Francis
Huntington's disease is associated with increased CAG repeat resulting in an expanded
polyglutamine tract in the protein Huntingtin (HTT) leading to its aggregation resulting in …
polyglutamine tract in the protein Huntingtin (HTT) leading to its aggregation resulting in …