Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …

Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

Despite compelling rates of durable clinical responses to programmed cell death-1 (PD-1)
blockade, advances are needed to extend these benefits to resistant tumors. We found that …

Stromal cells (SCs) establish the compartmentalization of lymphoid tissues critical to the
immune response. However, the full diversity of lymph node (LN) SCs remains undefined …

Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that
occupies tissues without recirculating. They provide a first response against infections …

T-lymphocytes play a critical role in cancer immunity as evidenced by their presence in
resected tumor samples derived from long-surviving patients, and impressive clinical …

Follicular CD8+ T cells (fCD8) mediate surveillance in lymph node (LN) germinal centers
against lymphotropic infections and cancers, but the precise mechanisms by which these …

While blood antibodies mediate protective immunity in most organs, whether they protect
nasal surfaces in the upper airway is unclear. Using multiple viral infection models in mice …

Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …

T cell migration is essential for T cell responses; it allows for the detection of cognate antigen
at the surface of antigen-presenting cells and for interactions with other cells involved in the …