Protein phosphorylation is the most common reversible post-translational modification in
eukaryotes. Humans have over 500 protein kinases, of which more than a dozen are …

G protein‐coupled receptors (GPCRs) are membrane‐bound proteins that are ubiquitously
expressed in many cell types and take part in mediating multiple signaling pathways …

The 23 human zinc finger Asp-His-His-Cys motif-containing (ZDHHC) S-acyltransferases
catalyze long-chain S-acylation at cysteine residues across an extensive network of …

Specificity within protein kinase signaling cascades is determined by direct and indirect
interactions between kinases and their substrates. While the impact of localization and …

Although multiple components of the cell membrane modulate the stability and activation of
G protein-coupled receptors (GPCRs), insights into the dynamics of GPCR structures come …

The objective of this experiment was to identify genome-wide differential methylation of DNA
in young prenatally stressed (PNS) bull calves. Mature Brahman cows (n= 48) were …

Signal transduction relies largely on the activity of kinases and phosphatases that control
protein phosphorylation. However, we still know very little about phosphorylation-mediated …

Cooperative interactions in protein-protein interfaces demonstrate the interdependency or
the linked network-like behavior and their effect on the coupling of proteins. Cooperative …

ER/K α-helices are a subset of single alpha helical domains, which exhibit unusual stability
as isolated protein secondary structures. They adopt an elongated structural conformation …

Protein kinases achieve substrate selective phosphorylation through their conformational
flexibility and dynamic interaction with the substrate. Designing substrate selective or kinase …