Recent progress in chemistry and bioactivity of monoterpenoid indole alkaloids from the genus gelsemium: a comprehensive review

L Wang, S Chen, X Gao, X Liang, W Lv… - Journal of Enzyme …, 2023 - Taylor & Francis
Monoterpenoid indole alkaloids (MIAs) represent a major class of active ingredients from the
plants of the genus Gelsemium. Gelsemium MIAs with diverse chemical structures can be …

Regulation of microglia related neuroinflammation contributes to the protective effect of Gelsevirine on ischemic stroke

C Xing, J Lv, Z Zhu, W Cong, H Bian, C Zhang… - Frontiers in …, 2023 - frontiersin.org
Stroke, especially ischemic stroke, is an important cause of neurological morbidity and
mortality worldwide. Growing evidence suggests that the immune system plays an intricate …

Reference Genes Screening and Gene Expression Patterns Analysis Involved in Gelsenicine Biosynthesis under Different Hormone Treatments in Gelsemium …

Y Zhang, D Mu, L Wang, X Wang, IW Wilson… - International Journal of …, 2023 - mdpi.com
Reverse transcription quantitative polymerase chain reaction (RT-qPCR) is an accurate
method for quantifying gene expression levels. Choosing appropriate reference genes to …

Identification of toxic Gelsemium elegans in processed food and honey based on real-time PCR analysis

G Wang, Y Ren, Y Su, H Zhang, J Li, H Zhao… - Food Research …, 2024 - Elsevier
Gelsemium elegans (GE) is a widely distributed hypertoxic plant that has caused many food
poisoning incidents. Its pollen can also be collected by bees to produce toxic honey, posing …

[HTML][HTML] Koumine ameliorates neuroinflammation by regulating microglia polarization via activation of Nrf2/HO-1 pathway

L Wang, Y Ding, Y Wu, C Zhao, J Wu, W Wang… - Biomedicine & …, 2023 - Elsevier
Abstract Background Gelsemium elegans (Gardner & Chapm.) Benth (G. elegans) has been
widely used as a traditional folk medicine in China and Southeast Asia. As the most …

Synthesis of 3-arylamino-2-polyhydroxyalkyl-substituted indoles from unprotected saccharides and anilines

J Wu, L Zhou, S Xie, C Wei, X Li, H Chen - Green Chemistry, 2024 - pubs.rsc.org
A simple and efficient one-pot synthetic protocol has been developed for the synthesis of 3-
arylamino-2-polyhydroxyalkyl-substituted indoles by using unprotected sugars and aromatic …

New monoterpenoid indole alkaloids from Gelsemium elegans seeds

A Saito, C Fujita, N Kogure, NT Vung, H Takayama… - Tetrahedron, 2022 - Elsevier
Three new monoterpenoid indole alkaloids, gelsevietmines-A, B, C (1–3), were isolated from
Gelsemium elegans seeds collected in Vietnam. Their unique and highly oxidized structures …

Gelselegine-gelsedine type bisindoles as well as the units from Gelsemium elegans with promoting proliferation of oral mucosa fibroblast cells

J Lin, J Wu, MF Bao, S Kongkiatpaiboon, XH Cai - Phytochemistry, 2024 - Elsevier
Two undescribed bisindole alkaloids, gelseginedine A (1) and its rearranged gelseginedine
B (2), and seven unreported gelselegine-type oxindole alkaloids (3–9) were isolated from …

Tracing of Gelsemium elegans by UPLC-Q-TOF MS fingerprint analysis technique

T Liu, X Wu, L Dong, J Li, L Zhao, C Zhang… - Microchemical …, 2024 - Elsevier
Fingerprints of 13 batches of Gelsemium elegans (G. elegans) were established by ultra-
performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry …

Ethyl Lithospermate Reduces Lipopolysaccharide-Induced Inflammation through Inhibiting NF-κB and STAT3 Pathways in RAW 264.7 Cells and Zebrafish

C Zhou, H Yang, L Zou, D Liu, L Yu, H Cao… - Chinese Journal of …, 2023 - Springer
Objective To explore the anti-inflammatory effects of ethyl lithospermate in
lipopolysaccharide (LPS)-stimulated RAW 264.7 murine-derived macrophages and …