Atopic dermatitis endotypes and implications for targeted therapeutics

T Czarnowicki, H He, JG Krueger… - Journal of Allergy and …, 2019 - Elsevier
Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …

[HTML][HTML] Cytokines, hormones and cellular regulatory mechanisms favoring successful reproduction

MP Piccinni, R Raghupathy, S Saito… - Frontiers in …, 2021 - frontiersin.org
Its semi-allogeneic nature renders the conceptus vulnerable to attack by the maternal
immune system. Several protective mechanisms operate during gestation to correct the …

Efficacy and safety of lebrikizumab, a high-affinity interleukin 13 inhibitor, in adults with moderate to severe atopic dermatitis: a phase 2b randomized clinical trial

E Guttman-Yassky, A Blauvelt, LF Eichenfield… - JAMA …, 2020 - jamanetwork.com
Importance Interleukin 13 (IL-13) is a central pathogenic mediator driving multiple features of
atopic dermatitis (AD) pathophysiology. Objective To evaluate the efficacy and safety of …

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis

T Werfel, JP Allam, T Biedermann, K Eyerich… - Journal of allergy and …, 2016 - Elsevier
Atopic dermatitis (AD) is a complex skin disease frequently associated with other diseases of
the atopic diathesis. Recent evidence supports the concept that AD can also recognize other …

Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis

H He, R Bissonnette, J Wu, A Diaz, ESC Proulx… - Journal of Allergy and …, 2021 - Elsevier
Background Our current understanding of atopic dermatitis (AD) and psoriasis
pathophysiology is largely derived from skin biopsy studies that cause scarring and may be …

CD4 + T-cell subsets in inflammatory diseases: beyond the T h 1/T h 2 paradigm

K Hirahara, T Nakayama - International immunology, 2016 - academic.oup.com
CD4+ T cells are crucial for directing appropriate immune responses during host defense
and for the pathogenesis of inflammatory diseases. In addition to the classical biphasic …

The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization

S Noda, M Suárez-Fariñas, B Ungar, SJ Kim… - Journal of Allergy and …, 2015 - Elsevier
Background Atopic dermatitis (AD) shows very high prevalence in Asia, with a large unmet
need for effective therapeutics. Direct comparisons between European American (EA) and …

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

O Palomares, M Akdis, M Martín‐Fontecha… - Immunological …, 2017 - Wiley Online Library
Allergy is a major public health problem with a high socio‐economic impact. The number of
allergic patients is expected to reach to four billion within two decades when the World's …

IL‐17 and IL‐22 in immunity: Driving protection and pathology

K Eyerich, V Dimartino, A Cavani - European journal of …, 2017 - Wiley Online Library
IL‐17 and IL‐22 are tissue‐signaling cytokines that favor protection and regeneration of
barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share …

[HTML][HTML] Increasing comorbidities suggest that atopic dermatitis is a systemic disorder

PM Brunner, JI Silverberg, E Guttman-Yassky… - Journal of Investigative …, 2017 - Elsevier
Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food
allergy, asthma, allergic rhinitis, allergic conjunctivitis, and eosinophilic esophagitis) …