Efficacy and safety of ustekinumab treatment in adults with moderate‐to‐severe atopic dermatitis

S Khattri, PM Brunner, S Garcet… - Experimental …, 2017 - Wiley Online Library
Atopic dermatitis (AD) is the most common inflammatory skin disease, but treatment options
for moderate‐to‐severe disease are limited. Ustekinumab is an IL‐12/IL‐23p40 antagonist …

[HTML][HTML] Expert perspectives on management of moderate-to-severe atopic dermatitis: a multidisciplinary consensus addressing current and emerging therapies

M Boguniewicz, AF Alexis, LA Beck, J Block… - The Journal of Allergy …, 2017 - Elsevier
Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease that
affects children and adults. Until recently, the only Food and Drug Administration–approved …

The proteomic skin profile of moderate-to-severe atopic dermatitis patients shows an inflammatory signature

AB Pavel, L Zhou, A Diaz, B Ungar, J Dan, H He… - Journal of the American …, 2020 - Elsevier
Background Moderate-to-severe atopic dermatitis (AD) is increasingly recognized as a
systemic disease, largely due to proteomic blood studies. There are growing efforts to …

Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options

T Bieber, AS Paller, K Kabashima… - Journal of the …, 2022 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, heterogenous, inflammatory skin disorder associated
with a high skin‐related health burden, typically starting in childhood and often persisting …

[HTML][HTML] An integrated model of atopic dermatitis biomarkers highlights the systemic nature of the disease

B Ungar, S Garcet, J Gonzalez, N Dhingra… - Journal of Investigative …, 2017 - Elsevier
Current atopic dermatitis (AD) models link epidermal abnormalities in lesional skin to
cytokine activation. However, there is evolving evidence of systemic immune activation and …

Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities

H He, E Del Duca, A Diaz, HJ Kim… - Journal of Allergy and …, 2021 - Elsevier
Background Molecular studies in atopic dermatitis (AD) are largely restricted to patients with
moderate-to-severe disease. Objective Our aim was to evaluate skin and blood …

Current insights into immunology and novel therapeutics of atopic dermatitis

HA Kader, M Azeem, SA Jwayed, A Al-Shehhi… - Cells, 2021 - mdpi.com
Atopic dermatitis (AD) is one of the most prevalent inflammatory disease among non-fatal
skin diseases, affecting up to one fifth of the population in developed countries. AD is …

Immunologic, microbial, and epithelial interactions in atopic dermatitis

PM Brunner, DYM Leung, E Guttman-Yassky - Annals of Allergy, Asthma & …, 2018 - Elsevier
Objective To provide an overview of studies contributing to the understanding of
immunologic, microbial, and epithelial interactions in atopic dermatitis. Data Sources …

The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and pruritus

P Rerknimitr, A Otsuka, C Nakashima… - Inflammation and …, 2017 - Springer
Atopic dermatitis (AD) is a common chronic skin inflammatory disorder characterized by
recurrent eczema accompanied by an intractable itch that leads to an impaired quality of life …

Endophenotypic variations of atopic dermatitis by age, race, and ethnicity

T Nomura, J Wu, K Kabashima… - The Journal of Allergy and …, 2020 - Elsevier
Atopic dermatitis (AD) is a heterogeneous disease with unique clinical manifestations across
age groups and race/ethnicities. Characteristic molecular mechanisms, known as …