The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and pruritus

P Rerknimitr, A Otsuka, C Nakashima… - Inflammation and …, 2017 - Springer
Atopic dermatitis (AD) is a common chronic skin inflammatory disorder characterized by
recurrent eczema accompanied by an intractable itch that leads to an impaired quality of life …

Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)+ TH2/TH1 cell imbalance, whereas adults acquire CLA+ TH22/TC22 cell subsets

T Czarnowicki, H Esaki, J Gonzalez, D Malajian… - Journal of Allergy and …, 2015 - Elsevier
Background Identifying differences and similarities between cutaneous lymphocyte antigen
(CLA)+ polarized T-cell subsets in children versus adults with atopic dermatitis (AD) is …

The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment

P Facheris, J Jeffery, E Del Duca… - Cellular & Molecular …, 2023 - nature.com
Atopic dermatitis (AD) is the most common inflammatory skin disease, and it is considered a
complex and heterogeneous condition. Different phenotypes of AD, defined according to the …

Current insights into immunology and novel therapeutics of atopic dermatitis

HA Kader, M Azeem, SA Jwayed, A Al-Shehhi… - Cells, 2021 - mdpi.com
Atopic dermatitis (AD) is one of the most prevalent inflammatory disease among non-fatal
skin diseases, affecting up to one fifth of the population in developed countries. AD is …

Effect of oral administration of a mixture of probiotic strains on SCORAD index and use of topical steroids in young patients with moderate atopic dermatitis: a …

V Navarro-López, A Ramírez-Boscá… - JAMA …, 2018 - jamanetwork.com
Importance Oral intake of new probiotic formulations may improve the course of atopic
dermatitis (AD) in a young population. Objective To determine whether a mixture of oral …

Endophenotypic variations of atopic dermatitis by age, race, and ethnicity

T Nomura, J Wu, K Kabashima… - The Journal of Allergy and …, 2020 - Elsevier
Atopic dermatitis (AD) is a heterogeneous disease with unique clinical manifestations across
age groups and race/ethnicities. Characteristic molecular mechanisms, known as …

Petrolatum: barrier repair and antimicrobial responses underlying this “inert” moisturizer

T Czarnowicki, D Malajian, S Khattri, JC da Rosa… - Journal of Allergy and …, 2016 - Elsevier
Background Petrolatum is a common moisturizer often used in the prevention of skin
infections after ambulatory surgeries and as a maintenance therapy of atopic dermatitis …

An update on the pathophysiology of atopic dermatitis

K Malik, KD Heitmiller, T Czarnowicki - Dermatologic Clinics, 2017 - derm.theclinics.com
AD is a complex, multifactorial disease. Immune dysregulation, barrier impairment, microbial
shifts, environmental factors, and genetic propensity all orchestrate the disease phenotype …

Molecular mechanisms of cutaneous inflammatory disorder: atopic dermatitis

JE Kim, JS Kim, DH Cho, HJ Park - International journal of molecular …, 2016 - mdpi.com
Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions
between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly …

Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism …

DA Ewald, D Malajian, JG Krueger, CT Workman… - BMC medical …, 2015 - Springer
Background Atopic dermatitis (AD) is a common inflammatory skin disease with limited
treatment options. Several microarray experiments have been conducted on lesional/LS and …