Blood endotyping distinguishes the profile of vitiligo from that of other inflammatory and autoimmune skin diseases

T Czarnowicki, H He, A Leonard, HJ Kim… - Journal of Allergy and …, 2019 - Elsevier
Background Peripheral blood skin-homing/cutaneous lymphocyte antigen (CLA)+ T cells
emerge as biomarkers of cutaneous immune activation in patients with inflammatory skin …

Immunologic targets in atopic dermatitis and emerging therapies: an update

D Wang, LA Beck - American journal of clinical dermatology, 2016 - Springer
Atopic dermatitis is one of the most common chronic inflammatory skin diseases. It usually
begins in childhood, has a considerable impact on patients' quality of life, and incurs …

Targeting the T helper 2 inflammatory axis in atopic dermatitis

AS Moreno, R McPhee, LK Arruda… - International archives of …, 2016 - karger.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects up to 25% of
children and 10% of adults. The skin of patients with moderate to severe AD is characterized …

Skin‐homing T‐cell responses associated with Demodex infestation and rosacea

U Gazi, AS Gureser, A Oztekin… - Parasite …, 2019 - Wiley Online Library
Aims Our aim was to investigate the skin‐homing T‐cell immune responses triggered in
patients with Demodex infestation and/or rosacea. Methods Collected whole blood samples …

[HTML][HTML] JAK1/JAK2 degraders based on PROTAC for topical treatment of atopic dermatitis

J Wu, L Li, Q Zhu, T Zhang, F Miao, Z Cui… - Biomedicine & …, 2024 - Elsevier
Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease. The Janus kinase
(JAK) has been identified as a target in AD, as it regulates specific inflammatory genes and …

Anti‐inflammatory therapies in atopic dermatitis

A Heratizadeh, T Werfel - Allergy, 2016 - Wiley Online Library
The pathogenesis of atopic dermatitis (AD) is multifactorial and complex. Consequently,
clinical signs and symptoms vary strongly depending on individually relevant trigger factors …

α-NAC–specific autoreactive CD8+ T cells in atopic dermatitis are of an effector memory type and secrete IL-4 and IFN-γ

LM Roesner, A Heratizadeh, S Wieschowski… - The Journal of …, 2016 - journals.aai.org
Autoreactivity may play a critical role in the chronification of atopic dermatitis (AD). Several
studies showed that AD patients produce IgE Abs specific for autoantigens, and we …

The IL-4/-13 axis and its blocking in the treatment of atopic dermatitis

G Pappa, D Sgouros, K Theodoropoulos… - Journal of Clinical …, 2022 - mdpi.com
Atopic dermatitis (AD) is a common inflammatory skin disease with a complex
pathophysiology, intertwining immune dysregulation, epidermal barrier dysfunction, IgE …

Unraveling the skin; a comprehensive review of atopic dermatitis, current understanding, and approaches

M Afshari, M Kolackova, M Rosecka… - Frontiers in …, 2024 - frontiersin.org
Atopic dermatitis, also known as atopic eczema, is a chronic inflammatory skin disease
characterized by red pruritic skin lesions, xerosis, ichthyosis, and skin pain. Among the …

CLA+ memory T cells in atopic dermatitis: CLA+ T cells and atopic dermatitis

LSS Nicolàs, T Czarnowicki, M Akdis, RM Pujol… - Allergy, 2024 - Wiley Online Library
Circulating skin‐homing cutaneous lymphocyte‐associated antigen (CLA)+ T cells constitute
a small subset of human memory T cells involved in several aspects of atopic dermatitis …