The literature reviewed herein clearly demonstrates the poor correlation between drug
dosing and the ability to achieve a specific serum drug concentration and between drug …

The idea of using a measured concentration to help decide the optimum dose of a drug and
consequently derive the maximum therapeutic benefit with the minimum risk of side effects is …

The experience of therapeutic drug monitoring (TDM) of seven drugs as part of the normal
biochemistry services over the period April 1982–83 is reported. Reagent costs alone for …

Objective: To review the pharmacodynamic and pharmacokinetic properties of digoxin in
health and disease and the potential use and toxic effects of digoxin in the critically ill …

In a study of the use of a digoxin assay service and its influence on clinical management 285
assay requests were audited over 12 weeks. For 67 (24%) there was no clear clinical …

Therapeutic drug monitoring (TOM) has a relatively brief history in clinical laboratories, I
beginning in the mid-1970s. Early work described the assistance TOM could provide in …

Immunoreactive digoxin was determined in blood samples of 73 patients with liver disease
who did not take any cardiac glycoside. Seventeen of these patients reproducibly showed …

The digoxin therapeutic drug monitoring service was evaluated during a 7‐week period at
Leeds General Infirmary. Data were collected for 88 patients who had one or more assays …

Due to the narrow therapeutic-to-toxic ratio of digoxin, numerous studies have been done to
assess the optimal digoxin level in patients with congestive heart faiiure. A digoxin level of …

In 3 groups of unselected hospitalised patients treated with digoxin (n= 300), gentamicin (n=
140) or theophylline (n= 120), physicians' special request forms for routinely performed …