Systematic review and meta-analysis of statin use and mortality, intensive care unit admission and requirement for mechanical ventilation in COVID-19 patients

US Lao, CF Law, DT Baptista-Hon… - Journal of Clinical …, 2022 - mdpi.com
There is mounting evidence that statin use is beneficial for COVID-19 outcomes. We
performed a systematic review and meta-analysis to evaluate the association between statin …

[HTML][HTML] A practical treatment for COVID‐19 and the next pandemic

J Bhattacharya, R Booy, A Casadevall… - Pharmacology …, 2022 - ncbi.nlm.nih.gov
Scientists are concerned about the origins of SARS-CoV-2, which has caused a devastating
global pandemic. In a letter recently published in Science, 18 investigators called for more …

Association of statins for primary prevention of cardiovascular diseases with hospitalization for COVID‐19: A nationwide matched population‐based cohort study

K Bouillon, B Baricault, L Semenzato… - Journal of the …, 2022 - Am Heart Assoc
Background There is little evidence on the relationship between statin use and the risk of
hospitalization attributable to COVID‐19. Methods and Results The French National …

Association of blood viscosity with mortality among patients hospitalized with COVID-19

D Choi, O Waksman, A Shaik, P Mar, Q Chen… - Journal of the American …, 2022 - jacc.org
Abstract Background Coronavirus disease-2019 (COVID-19) is characterized by a
dysfunctional immune response and abnormal blood rheology that contribute to endothelial …

Repurposing low-dose naltrexone for the prevention and treatment of immunothrombosis in COVID-19

B Pitt, AM Tate, D Gluck, RS Rosenson… - European Heart …, 2022 - academic.oup.com
Abstract Coronavirus disease 2019 (COVID-19) is characterized by striking dysregulation of
the immune system, with evidence of hyperinflammation, an impaired induction of …

Potential role of geranylgeraniol in managing statin-associated muscle symptoms: a COVID-19 related perspective

B Tan, KY Chin - Frontiers in Physiology, 2023 - frontiersin.org
Myopathy is the most common side effect of statins, but it has not been addressed effectively.
In anticipation of its wider use as a small molecule to complement the current COVID-19 …

Routine statins use is associated with less adverse outcome in patients above 70 years of age admitted to hospital with COVID-19

E Izkhakov, Y Vilian, A Buch, V Denysov, D Namouz… - BMC geriatrics, 2023 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to multiorgan insufficiency and …

Biological actions, implications, and cautions of statins therapy in COVID-19

C Liu, W Yan, J Shi, S Wang, A Peng, Y Chen… - Frontiers in …, 2022 - frontiersin.org
The Coronavirus Disease 2019 (COVID-19) showed worse prognosis and higher mortality in
individuals with obesity. Dyslipidemia is a major link between obesity and COVID-19 …

PCSK9: the nexus of lipoprotein metabolism and inflammation in COVID-19

SN Goonewardena, RS Rosenson - Journal of the American College of …, 2023 - jacc.org
disease-2019(COVID-19) is caused by the severe acute respiratory syndrome-coronavirus-2
(SARS-CoV-2) and is associated with pathologic inflammation and thrombosis. Most COVID …

Treating COVID-19: targeting the host response, not the virus

DS Fedson - Life, 2023 - mdpi.com
In low-and middle-income countries (LMICs), inexpensive generic drugs like statins, ACE
inhibitors, and ARBs, especially if used in combination, might be the only practical way to …