Updates on Disease Mechanisms and Therapeutics for Amyotrophic Lateral Sclerosis

L Nguyen - Cells, 2024 - mdpi.com
Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a motor neuron disease. In
ALS, upper and lower motor neurons in the brain and spinal cord progressively degenerate …

[HTML][HTML] Deep learning modeling of rare noncoding genetic variants in human motor neurons defines CCDC146 as a therapeutic target for ALS

S Zhang, T Moll, J Rubin-Sigler, S Tu, S Li, E Yuan… - medRxiv, 2024 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease
caused by the selective and progressive death of motor neurons (MNs). Understanding the …

Creating and characterising physiological mouse models of SOD1-and C9orf72-ALS

D Thompson - 2024 - ora.ox.ac.uk
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterised by the loss of motor neurons. Mutations in the superoxide dismutase 1 (SOD1) …