Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Abstract Changes in chromatin structure mediated by ATP-dependent nucleosome
remodelers and histone modifying enzymes are integral to the process of gene regulation …

BCOR is a gene that encodes for an epigenetic regulator involved in the specification of cell
differentiation and body structure development and takes part in the noncanonical polycomb …

Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here,
we present an integrated analysis of transcriptome and chromatin accessibility of aged …

Despite advances in single-cell multi-omics, a single stem or progenitor cell can only be
tested once. We developed clonal multi-omics, in which daughters of a clone act as …

The BCL6 corepressor (BCOR) is a transcription factor involved in the control of
embryogenesis, mesenchymal stem cells function, hematopoiesis, and lymphoid …

Abstract The BCL6 Corepressor (BCOR) is a component of a variant Polycomb repressive
complex 1 (PRC1) that is essential for normal development. Recurrent mutations in the …

Aplastic anemia (AA) is the prototypic bone marrow failure syndrome and can be classified
as either acquired or inherited. Inherited forms are due to the effects of germline mutations …

Extranodal NK/T-cell lymphoma (ENKTL) is an Epstein-Barr virus (EBV) associated
lymphoma, prevalent in Asia and Latin America. Studies in Asian cohorts have identified …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological disease that
arises from the oncogenic transformation of developing T cells during T-lymphopoiesis …