Adhesion molecules mediate cell-to-cell and cell-to-extracellular matrix interactions and
transmit mechanical and chemical signals among them. Various mechanisms deregulate …

Simple Summary The tumor microenvironment plays an important role in drug resistance
and supports/promotes tumorigenesis. Stromal modulators in combination with …

Multiple myeloma (MM) is a cancer of bone marrow (BM) plasma cells, which is increasingly
treatable but still incurable. In 90% of MM patients, severe osteolysis results from …

Simple Summary Worldwide obesity has nearly tripled in the last fifty years. Obesity is a risk
factor for multiple myeloma, contributing to both an increased risk of multiple myeloma …

Drug resistance is a major obstacle to successful cancer treatment. Therefore, it is essential
to understand the molecular mechanisms underlying drug resistance to develop successful …

Chemotherapy is a critical treatment for endocrine-related cancers; however,
chemoresistance and disease recurrence remain a challenge. The interplay between cancer …

The prognosis of patients with multiple myeloma (MM) has improved dramatically with the
introduction of new therapeutic drugs, but the disease eventually becomes drug-resistant …

Tissue inhibitors of metalloproteinases (TIMPs) are endogenous matrix metalloproteinase
inhibitors. TIMP1 is produced by cancer cells and has pleiotropic activities. However, its role …

We previously reported that macrolide antibiotics, such as clarithromycin (CAM), blocked
autophagy flux, and simultaneous proteasome and autophagy inhibition by bortezomib …

Background S100A8, a calcium-binding protein belonging to the S100 family, is involved in
immune responses and multiple tumor pathogens. Diffuse large B-cell lymphoma (DLBCL) …