[HTML][HTML] Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing

S Patel, S Srivastava, MR Singh, D Singh - Biomedicine & …, 2019 - Elsevier
Wound management in diabetic patient is of an extreme clinical and social concern. The
delayed and impaired healing makes it more critical for research focus. The research on …

Why venous leg ulcers have difficulty healing: overview on pathophysiology, clinical consequences, and treatment

JD Raffetto, D Ligi, R Maniscalco, RA Khalil… - Journal of clinical …, 2020 - mdpi.com
Venous leg ulcers (VLUs) are one of the most common ulcers of the lower extremity. VLU
affects many individuals worldwide, could pose a significant socioeconomic burden to the …

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing

J Huang, R Yang, J Jiao, Z Li, P Wang, Y Liu… - Nature …, 2023 - nature.com
High glucose-induced vascular endothelial injury is a major pathological factor involved in
non-healing diabetic wounds. To interrupt this pathological process, we design an all …

Managing diabetic foot ulcers: pharmacotherapy for wound healing

D Dixon, M Edmonds - Drugs, 2021 - Springer
Historically, there has been a scarcity of evidence-based topical therapy to hasten the
healing of diabetic foot ulcers. But recently new evidence-based treatments have emerged …

Oxidative stress and lipid peroxidation: prospective associations between ferroptosis and delayed wound healing in diabetic ulcers

J Feng, J Wang, Y Wang, X Huang, T Shao… - Frontiers in cell and …, 2022 - frontiersin.org
Diabetic ulcers are one of the major complications of diabetes, and patients usually suffer
from amputation and death due to delayed ulcer wound healing. Persistent inflammation …

Development of a photosynthetic hydrogel as potential wound dressing for the local delivery of oxygen and bioactive molecules

R Corrales-Orovio, F Carvajal, C Holmes, M Miranda… - Acta Biomaterialia, 2023 - Elsevier
The development of biomaterials to improve wound healing is a critical clinical challenge
and an active field of research. As it is well described that oxygen plays a critical role in …

Accelerated wound healing in a diabetic rat model using decellularized dermal matrix and human umbilical cord perivascular cells

PB Milan, N Lotfibakhshaiesh, MT Joghataie, J Ai… - Acta biomaterialia, 2016 - Elsevier
There is an unmet clinical need for novel wound healing strategies to treat full thickness skin
defects, especially in diabetic patients. We hypothesized that a scaffold could perform dual …

Extracellular vesicle-based therapeutics for the regeneration of chronic wounds: current knowledge and future perspectives

P Lou, S Liu, X Xu, C Pan, Y Lu, J Liu - Acta biomaterialia, 2021 - Elsevier
Chronic wounds are still an intractable medical problem for both clinicians and researchers
and cause a substantial social and medical burden. Current clinical approaches can only …

Healing of chronic wounds: an update of recent developments and future possibilities

MH Kathawala, WL Ng, D Liu, MW Naing… - … Engineering Part B …, 2019 - liebertpub.com
Chronic wounds are the result of disruptions in the body's usual process of healing. They are
not only a source of significant pain and discomfort but also, more importantly, an unguarded …

Relevance of NLRP3 inflammasome‐related pathways in the pathology of diabetic wound healing and possible therapeutic targets

Y Ding, X Ding, H Zhang, S Li… - Oxidative Medicine and …, 2022 - Wiley Online Library
Wound healing is a major secondary complication in type 2 diabetes, which results in
significant disability and mortality, imposing a significant clinical and social burden …