Genetic variation is the major mechanism behind adaptation and evolutionary change. As
most proteins operate through interactions with other proteins, changes in protein complex …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Histone proteins bind DNA and organize the genomes of eukaryotes and most archaea,
whereas bacteria rely on different nucleoid-associated proteins. Homology searches have …

Eukaryotes and many archaea package their DNA with histones. While the four eukaryotic
histones wrap~ 147 DNA base pairs into nucleosomes, archaeal histones form 'nucleosome …

Abstract Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling,
which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various …

Through the association of protein complexes to DNA, the eukaryotic nuclear genome is
broadly organized into open euchromatin that is accessible for enzymes acting on DNA and …

Histones, ubiquitous in eukaryotes as DNA-packing proteins, find their evolutionary origins
in archaea. Unlike the characterized histone proteins of a number of methanogenic and …

In archaea, histones play a role in genome compaction and are involved in transcription
regulation. Whereas archaeal histones bind DNA without sequence specificity, they bind …

In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B
that assemble into octameric nucleosome particles. Archaeal histones are dimeric and …

The three domains of life employ various strategies to organize their genomes. Archaea
utilize features similar to those found in both eukaryotic and bacterial chromatin to organize …