Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and
neurodegenerative disorders. Although we are far from understanding the biological basis of …

Discriminating the contribution of unmodifiable random intrinsic DNA replication errors ('bad
luck') to cancer development from those of other factors is critical for understanding cancer in …

Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …

Human aging is a multifactorial phenomenon that affects numerous organ systems and
cellular processes, with the immune system being one of the most dysregulated …

Cellular senescence was first described by Hayflick and Moorhead in the 1960s as the
irreversible arrest of cells following prolonged cultivation. Telomere shortening is the key …

Background Cellular senescence, a permanent state of replicative arrest in otherwise
proliferating cells, is a hallmark of aging and has been linked to aging-related diseases …

Background and aims Clinical evidence exists that patients with diabetes are at higher risk
for Coronavirus disease 2019 (COVID-19). We investigated the physiological origins of this …

Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …

Damaged cells at risk of neoplastic transformation can be neutralized by apoptosis or
engagement of the senescence program, which induces permanent cell-cycle arrest and a …