Traditional risk factors for obesity and the metabolic syndrome, such as excess energy
intake and lack of physical activity, cannot fully explain the high prevalence of these …

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …

Time-restricted feeding (TRF) regimens have grown in popularity; however, very few studies
have examined their weight-loss efficacy. We conducted the first human trial (Clinicaltrials …

Late eating has been linked to obesity risk. It is unclear whether this is caused by changes in
hunger and appetite, energy expenditure, or both, and whether molecular pathways in …

Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether
these effects are due solely to weight loss. We conducted the first supervised controlled …

Morning loaded calorie intake in humans has been advocated as a dietary strategy to
improve weight loss. This is also supported by animal studies suggesting time of eating can …

Objective Eating earlier in the daytime to align with circadian rhythms in metabolism
enhances weight loss. However, it is unknown whether these benefits are mediated through …

The influence of meal frequency and timing on health and disease has been a topic of
interest for many years. While epidemiological evidence indicates an association between …

The importance of diet and the gut-brain axis for brain health and cognitive function is
increasingly acknowledged. Dietary interventions are tested for their potential to prevent …

The circadian system orchestrates metabolism in daily 24-hour cycles. Such rhythms
organize metabolism by temporally separating opposing metabolic processes and by …