The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of
digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone …

Pregnancy in placental mammals places unique demands on the insulin‐producing β‐cells
in the pancreatic islets of Langerhans. The pancreas anticipates the increase in insulin …

Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the
removal of impaired tissue and activation of a program leading to organ regeneration pose …

Successful strategies for treating type 1 diabetes need to restore the function of pancreatic
beta cells that are destroyed by the immune system and overcome further destruction of …

Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur
exclusively via the replication of existing beta cells, but clinically meaningful restoration of …

Determination of signaling pathways that regulate beta-cell replication is critical for beta-cell
therapy. Here, we show that blocking pancreatic macrophage infiltration after pancreatic …

We have described multipotent progenitor-like cells within the major pancreatic ducts
(MPDs) of the human pancreas. They express PDX1, its surrogate surface marker P2RY1 …

Type 2 diabetes (T2DM) is characterized by insulin resistance and beta-cell dysfunction.
Although insulin resistance is assumed to be a main pathophysiological feature of the …

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
are incretin hormones that control the secretion of insulin, glucagon, and somatostatin to …

Understanding the origin of pancreatic β cells has profound implications for regenerative
therapies in diabetes. For over a century, it was widely held that adult pancreatic duct cells …