The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival
factor which supports autoreactive B cells and prevents their deletion. BAFF expression is …

Abnormalities in B cells play pivotal roles in the pathogenesis of systemic lupus
erythematosus (SLE) and lupus nephritis (LN). Breach in central and peripheral tolerance …

Objective To evaluate the efficacy and safety of atacicept, an antagonist of B lymphocyte
stimulator/APRIL–mediated B cell activation, in patients with systemic lupus erythematosus …

The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-
inducing ligand), are critical factors in the maintenance of the B cell pool and humoral …

SLE is a chronic autoimmune disease caused by perturbations of the immune system. The
clinical presentation is heterogeneous, largely because of the multiple genetic and …

The pathogenic roles for B cells in autoimmunity include produce pathogenic autoantibodies
and modulate immune responses via the production of cytokines and chemokines. The B …

Plasma cells (PCs) are responsible for the production of protective antibodies against
infectious agents but they also produce pathogenic antibodies in autoimmune diseases …

B cells are central to the pathogenesis of multiple autoimmune diseases, through antigen
presentation, cytokine secretion, and the production of autoantibodies. During development …

Autoimmune diseases are characterized by the recognition of self‐antigens by the immune
system, which leads to inflammation and tissue damage. B cells are directly and indirectly …

B cells have important functions in the pathogenesis of autoimmune diseases, including
autoimmune rheumatic diseases. In addition to producing autoantibodies, B cells contribute …