Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by the
loss of memory, multiple cognitive impairments and changes in the personality and …

Evidence suggesting that central nervous system γ-aminobutyric acid (GABA)
concentrations are reduced in patients with major depressive disorder (MDD) has been …

The amygdala is a core component of neural circuits that mediate processing of emotional,
particularly anxiety and fear-related stimuli across species. In addition, the nuclear complex …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in which
the phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K)/protein kinase B (PKB or Akt) …

Mapping of the human brain is more than the generation of an atlas-based parcellation of
brain regions using histologic or histochemical criteria. It is the attempt to provide a …

5-hydroxytryptamine6 receptor (5-HT6R) antagonists have shown efficacy in animal models
for cognitive impairment in multiple cognitive domains relevant for schizophrenia …

Newborn neurons enter an extended maturation stage, during which they acquire excitability
characteristics crucial for development of presynaptic and postsynaptic connectivity. In …

Background: Optimal behavioral performance results from a balance between goal-directed
and habitual systems of behavioral control, which are modulated by ascending …

To date, there are no interventions that impede the inexorable progression of Alzheimer's
disease (AD), and currently-available drugs cholinesterase (AChE) inhibitors and the N …