Pharmacology and Therapeutic Potential of the 5-HT7 Receptor

KM Blattner, DJ Canney, DA Pippin… - ACS Chemical …, 2018 - ACS Publications
It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a
series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first …

Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis

E Jensen-Jarolim, I Pali-Schöll… - Current opinion in …, 2017 - journals.lww.com
Natural and artificial animal models were used to explore the pathophysiology of asthma,
food allergy and anaphylaxis and to improve prophylactic and therapeutic measures …

5-HT7 Receptor Contributes to Proliferation, Migration and Invasion in NSCLC Cells

X Du, T Wang, Z Wang, X Wu, Y Gu… - OncoTargets and …, 2020 - Taylor & Francis
Introduction Because only a small portion of NSCLC (non-small-cell lung cancer) patients
benefit from molecular targeted therapy or immunotherapy and do not develop therapeutic …

Mesenchymal stem cells attenuate the proinflammatory cytokine pattern in a guinea pig model of chronic cigarette smoke exposure

JL Arreola-Ramírez, MH Vargas, V Carbajal… - Cytokine, 2023 - Elsevier
Aims Cigarette smoke often induces pulmonary and systemic inflammation. In animal
models, mesenchymal stem cells (MSC) tend to ameliorate these effects. We aimed to …

Effects of intranasal treatment with slow (GYY4137) and rapid (NaHS) donors of hydrogen sulfide in lipopolysaccharide-induced airway inflammation in mice

Y Kaya-Yasar, Y Karaman, TE Bozkurt… - Pulmonary …, 2017 - Elsevier
We have investigated the effects of slow (GYY4137) and rapid (NaHS) hydrogen sulfide (H 2
S) releasing donors in lipopolysaccharide (LPS)-induced airway inflammation in mice. LPS …

Role of peripheral 5-HT5A receptors in 5-HT-induced cardiac sympatho-inhibition in type 1 diabetic rats

JÁ García-Pedraza, O Hernández-Abreu, A Morán… - Scientific Reports, 2020 - nature.com
HT inhibits cardiac sympathetic neurotransmission in normoglycaemic rats, via 5-HT1B, 5-
HT1D and 5-HT5A receptor activation. Since type 1 diabetes impairs the cardiac …

Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review

SL Thirumaran, A Lepailleur, C Rochais - European Journal of Medicinal …, 2019 - Elsevier
HT 7 receptors are the most recently discovered serotonergic receptors, for which numerous
physiological implications in the central and the peripheral nervous systems as well as the …

[HTML][HTML] Allergic sensitization increases contractile responses to 5-HT in guinea pig aorta

P Campos-Bedolla, DELACN Rafael… - Physiological …, 2020 - ncbi.nlm.nih.gov
Epidemiological and clinical studies suggest that asthma is associated with adverse
cardiovascular outcomes, but its mechanism is uncertain. 5-Hydroxytryptamine (5-HT) is a …

[PDF][PDF] The Role of Muscarinic M2 and M3 Receptor Subtypes in Cardiopulmonary Responsiveness: Insights from In Vivo Murine Models

S Vincent - 2020 - qspace.library.queensu.ca
Muscarinic receptors play an important role in cholinergic transmission and physiologic
events. However, the study of the mechanisms by which muscarinic receptors mediate …

Exclusive Peripheral Overexpression of 5-HT5A Receptors is Involved in 5‑HT‑Induced Cardiac Sympatho-Inhibition in Type 1 Diabetic Rats

JÁ Garcia-Pedraza, O Hernández-Abreu, A Morán… - 2020 - researchsquare.com
Background: In normoglycaemic pithed rats, cardiac sympathetic control is modulated by
serotonin (5-hydroxytryptamine; 5‑HT), which inhibits the cardioaccelerator sympathetic …