Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential …

AHH Ahmed, MFA Mohamed, RM Allam, A Nafady… - Bioorganic …, 2022 - Elsevier
Uncontrolled inflammation predisposes to pleiotropic effects leading to cancer development
thanks to promoting all stages of tumorigenesis. Therefore, cancer-associated inflammation …

[HTML][HTML] Ultrasound-assisted transition-metal-free catalysis: a sustainable route towards the synthesis of bioactive heterocycles

B Borah, LR Chowhan - RSC advances, 2022 - pubs.rsc.org
Heterocycles of synthetic and natural origin are a well-established class of compounds
representing a broad range of organic molecules that constitute over 60% of drugs and …

[HTML][HTML] Imidazole-pyridine hybrids as potent anti-cancer agents

B Aruchamy, C Drago, V Russo, GM Pitari… - European Journal of …, 2023 - Elsevier
In the current investigation, fifteen novel imidazole-pyridine-based molecules were
synthesized and tested against cell lines of the lung (H1299) and colon (HCT116) …

p53 as a potential target for treatment of cancer: A perspective on recent advancements in small molecules with structural insights and SAR studies

R Bhatia, B Kumar - European Journal of Medicinal Chemistry, 2023 - Elsevier
Cancer represents one of the world's biggest hazardous diseases. p53 is the uttermost
researched tumour suppressor protein. It is commonly considered the “guardian of the …

Biological activity of two anticancer Pt complexes with a cyclohexylglycine ligand against a colon cancer cell line: theoretical and experimental study

Z Hosseini-Hashemi, M Eslami Moghadam… - ACS …, 2022 - ACS Publications
Because of their extraordinary ability to disrupt the natural structure of nucleic acids, metal
complexes could be used in cancer therapy. In this study, cyclohexylglycine (HL) as a ligand …

Nanocarriers for transgene expression in pollen as a plant biotechnology tool

TTS Lew, M Park, Y Wang, P Gordiichuk… - ACS Materials …, 2020 - ACS Publications
As the male gametophyte of flowering plants, pollen grains are ideal targets for the
introduction of transgenes for plant genetic engineering and crop improvement. However …

[HTML][HTML] NiO nanocomposites/rGO as a heterogeneous catalyst for imidazole scaffolds with applications in inhibiting the DNA binding activity

G Kumar, NK Mogha, M Kumar, DT Masram - Dalton Transactions, 2020 - pubs.rsc.org
Herein, we report a facile approach to synthesize a new highly versatile heterogeneous
catalyst by spontaneous aerial oxidation based on nickel oxide nanocomposites …

An Insight into the Biological Properties of Imidazole‐Based Schiff Bases: A Review

AK Gopalakrishnan, SA Angamaly… - …, 2021 - Wiley Online Library
Imidazole is an azole heterocycle containing two non‐adjacent nitrogen atoms added
greatly to natural products and synthetic compounds. The planar ring system associated with …

[HTML][HTML] The combination of multi-approach studies to explore the potential therapeutic mechanisms of imidazole derivatives as an MCF-7 inhibitor in therapeutic …

M Rashid, A Maqbool, N Shafiq, YA Bin Jardan… - Frontiers in …, 2023 - frontiersin.org
Breast cancer covers a large area of research because of its prevalence and high frequency
all over the world. This study is based on drug discovery against breast cancer from a series …

[HTML][HTML] Transcriptomics and flow cytometry reveals the cytotoxicity of aflatoxin B1 and aflatoxin M1 in bovine mammary epithelial cells

K Wu, S Jia, J Zhang, C Zhang, S Wang… - Ecotoxicology and …, 2021 - Elsevier
Aflatoxin is a known mycotoxin that pollutes various grains widely in the environment.
Aflatoxin B 1 (AFB 1) and Aflatoxin M 1 (AFM 1) have been shown to induce cytotoxicity in …