Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential …
AHH Ahmed, MFA Mohamed, RM Allam, A Nafady… - Bioorganic …, 2022 - Elsevier
Uncontrolled inflammation predisposes to pleiotropic effects leading to cancer development
thanks to promoting all stages of tumorigenesis. Therefore, cancer-associated inflammation …
thanks to promoting all stages of tumorigenesis. Therefore, cancer-associated inflammation …
[HTML][HTML] Ultrasound-assisted transition-metal-free catalysis: a sustainable route towards the synthesis of bioactive heterocycles
B Borah, LR Chowhan - RSC advances, 2022 - pubs.rsc.org
Heterocycles of synthetic and natural origin are a well-established class of compounds
representing a broad range of organic molecules that constitute over 60% of drugs and …
representing a broad range of organic molecules that constitute over 60% of drugs and …
[HTML][HTML] Imidazole-pyridine hybrids as potent anti-cancer agents
B Aruchamy, C Drago, V Russo, GM Pitari… - European Journal of …, 2023 - Elsevier
In the current investigation, fifteen novel imidazole-pyridine-based molecules were
synthesized and tested against cell lines of the lung (H1299) and colon (HCT116) …
synthesized and tested against cell lines of the lung (H1299) and colon (HCT116) …
p53 as a potential target for treatment of cancer: A perspective on recent advancements in small molecules with structural insights and SAR studies
Cancer represents one of the world's biggest hazardous diseases. p53 is the uttermost
researched tumour suppressor protein. It is commonly considered the “guardian of the …
researched tumour suppressor protein. It is commonly considered the “guardian of the …
Biological activity of two anticancer Pt complexes with a cyclohexylglycine ligand against a colon cancer cell line: theoretical and experimental study
Z Hosseini-Hashemi, M Eslami Moghadam… - ACS …, 2022 - ACS Publications
Because of their extraordinary ability to disrupt the natural structure of nucleic acids, metal
complexes could be used in cancer therapy. In this study, cyclohexylglycine (HL) as a ligand …
complexes could be used in cancer therapy. In this study, cyclohexylglycine (HL) as a ligand …
Nanocarriers for transgene expression in pollen as a plant biotechnology tool
As the male gametophyte of flowering plants, pollen grains are ideal targets for the
introduction of transgenes for plant genetic engineering and crop improvement. However …
introduction of transgenes for plant genetic engineering and crop improvement. However …
[HTML][HTML] NiO nanocomposites/rGO as a heterogeneous catalyst for imidazole scaffolds with applications in inhibiting the DNA binding activity
Herein, we report a facile approach to synthesize a new highly versatile heterogeneous
catalyst by spontaneous aerial oxidation based on nickel oxide nanocomposites …
catalyst by spontaneous aerial oxidation based on nickel oxide nanocomposites …
An Insight into the Biological Properties of Imidazole‐Based Schiff Bases: A Review
AK Gopalakrishnan, SA Angamaly… - …, 2021 - Wiley Online Library
Imidazole is an azole heterocycle containing two non‐adjacent nitrogen atoms added
greatly to natural products and synthetic compounds. The planar ring system associated with …
greatly to natural products and synthetic compounds. The planar ring system associated with …
[HTML][HTML] The combination of multi-approach studies to explore the potential therapeutic mechanisms of imidazole derivatives as an MCF-7 inhibitor in therapeutic …
Breast cancer covers a large area of research because of its prevalence and high frequency
all over the world. This study is based on drug discovery against breast cancer from a series …
all over the world. This study is based on drug discovery against breast cancer from a series …
[HTML][HTML] Transcriptomics and flow cytometry reveals the cytotoxicity of aflatoxin B1 and aflatoxin M1 in bovine mammary epithelial cells
K Wu, S Jia, J Zhang, C Zhang, S Wang… - Ecotoxicology and …, 2021 - Elsevier
Aflatoxin is a known mycotoxin that pollutes various grains widely in the environment.
Aflatoxin B 1 (AFB 1) and Aflatoxin M 1 (AFM 1) have been shown to induce cytotoxicity in …
Aflatoxin B 1 (AFB 1) and Aflatoxin M 1 (AFM 1) have been shown to induce cytotoxicity in …