Mechanisms of stem cell therapy in spinal cord injuries

M Shinozaki, N Nagoshi, M Nakamura, H Okano - Cells, 2021 - mdpi.com
Every year, 0.93 million people worldwide suffer from spinal cord injury (SCI) with
irretrievable sequelae. Rehabilitation, currently the only available treatment, does not …

The comparative effects of mesenchymal stem cell transplantation therapy for spinal cord injury in humans and animal models: a systematic review and meta-analysis

LDV Johnson, MR Pickard, WEB Johnson - Biology, 2021 - mdpi.com
Simple Summary The effects of mesenchymal stem cell (MSC) transplants on functional
recovery after spinal cord injury have been compared in humans and animal models. Data …

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord

KL Lankford, EJ Arroyo, K Nazimek, K Bryniarski… - PloS one, 2018 - journals.plos.org
In a previous report we showed that intravenous infusion of bone marrow-derived
mesenchymal stem cells (MSCs) improved functional recovery after contusive spinal cord …

Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and …

M Nakazaki, T Morita, KL Lankford… - Journal of …, 2021 - Wiley Online Library
Intravenous (IV) infusion of bone marrow‐derived mesenchymal stem/stromal cells (MSCs)
stabilizes the blood‐spinal cord barrier (BSCB) and improves functional recovery in …

MSC-derived exosomes attenuate cell death through suppressing AIF nucleus translocation and enhance cutaneous wound healing

G Zhao, F Liu, Z Liu, K Zuo, B Wang, Y Zhang… - Stem cell research & …, 2020 - Springer
Background Skin wounding is very common and may be slow to heal. Increasing evidence
shows that exosomes derived from mesenchymal stem cells (MSCs) dramatically enhance …

Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative …

T Gao, F Huang, W Wang, Y Xie, B Wang - Cellular & molecular biology …, 2022 - Springer
Background After spinal cord injury (SCI), dysregulated or nonresolving inflammatory
processes can severely disturb neuronal homeostasis and drive neurodegeneration …

Targeted delivery of mesenchymal stem cell-derived nanovesicles for spinal cord injury treatment

JR Lee, JW Kyung, H Kumar, SP Kwon… - International Journal of …, 2020 - mdpi.com
Due to the safety issues and poor engraftment of mesenchymal stem cell (MSC)
implantation, MSC-derived exosomes have been spotlighted as an alternative therapy for …

Molecular approaches for spinal cord injury treatment

FM de Almeida, SA Marques… - Neural Regeneration …, 2023 - journals.lww.com
Injuries to the spinal cord result in permanent disabilities that limit daily life activities. The
main reasons for these poor outcomes are the limited regenerative capacity of central …

Injection of bone marrow mesenchymal stem cells by intravenous or intraperitoneal routes is a viable alternative to spinal cord injury treatment in mice

B dos Santos Ramalho, FM de Almeida… - Neural regeneration …, 2018 - journals.lww.com
In spite of advances in surgical care and rehabilitation, the consequences of spinal cord
injury (SCI) are still challenging. Several experimental therapeutic strategies have been …

Mesenchymal stem cells transplanted into spinal cord injury adopt immune cell-like characteristics

R Hakim, R Covacu, V Zachariadis, A Frostell… - Stem Cell Research & …, 2019 - Springer
Abstract Background Mesenchymal stem cells (MSCs) and their cellular response to various
stimuli have been characterized in great detail in culture conditions. In contrast, the cellular …