Mechanisms of stem cell therapy in spinal cord injuries
Every year, 0.93 million people worldwide suffer from spinal cord injury (SCI) with
irretrievable sequelae. Rehabilitation, currently the only available treatment, does not …
irretrievable sequelae. Rehabilitation, currently the only available treatment, does not …
The comparative effects of mesenchymal stem cell transplantation therapy for spinal cord injury in humans and animal models: a systematic review and meta-analysis
LDV Johnson, MR Pickard, WEB Johnson - Biology, 2021 - mdpi.com
Simple Summary The effects of mesenchymal stem cell (MSC) transplants on functional
recovery after spinal cord injury have been compared in humans and animal models. Data …
recovery after spinal cord injury have been compared in humans and animal models. Data …
Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord
KL Lankford, EJ Arroyo, K Nazimek, K Bryniarski… - PloS one, 2018 - journals.plos.org
In a previous report we showed that intravenous infusion of bone marrow-derived
mesenchymal stem cells (MSCs) improved functional recovery after contusive spinal cord …
mesenchymal stem cells (MSCs) improved functional recovery after contusive spinal cord …
Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and …
M Nakazaki, T Morita, KL Lankford… - Journal of …, 2021 - Wiley Online Library
Intravenous (IV) infusion of bone marrow‐derived mesenchymal stem/stromal cells (MSCs)
stabilizes the blood‐spinal cord barrier (BSCB) and improves functional recovery in …
stabilizes the blood‐spinal cord barrier (BSCB) and improves functional recovery in …
MSC-derived exosomes attenuate cell death through suppressing AIF nucleus translocation and enhance cutaneous wound healing
G Zhao, F Liu, Z Liu, K Zuo, B Wang, Y Zhang… - Stem cell research & …, 2020 - Springer
Background Skin wounding is very common and may be slow to heal. Increasing evidence
shows that exosomes derived from mesenchymal stem cells (MSCs) dramatically enhance …
shows that exosomes derived from mesenchymal stem cells (MSCs) dramatically enhance …
Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative …
T Gao, F Huang, W Wang, Y Xie, B Wang - Cellular & molecular biology …, 2022 - Springer
Background After spinal cord injury (SCI), dysregulated or nonresolving inflammatory
processes can severely disturb neuronal homeostasis and drive neurodegeneration …
processes can severely disturb neuronal homeostasis and drive neurodegeneration …
Targeted delivery of mesenchymal stem cell-derived nanovesicles for spinal cord injury treatment
Due to the safety issues and poor engraftment of mesenchymal stem cell (MSC)
implantation, MSC-derived exosomes have been spotlighted as an alternative therapy for …
implantation, MSC-derived exosomes have been spotlighted as an alternative therapy for …
Molecular approaches for spinal cord injury treatment
FM de Almeida, SA Marques… - Neural Regeneration …, 2023 - journals.lww.com
Injuries to the spinal cord result in permanent disabilities that limit daily life activities. The
main reasons for these poor outcomes are the limited regenerative capacity of central …
main reasons for these poor outcomes are the limited regenerative capacity of central …
Injection of bone marrow mesenchymal stem cells by intravenous or intraperitoneal routes is a viable alternative to spinal cord injury treatment in mice
B dos Santos Ramalho, FM de Almeida… - Neural regeneration …, 2018 - journals.lww.com
In spite of advances in surgical care and rehabilitation, the consequences of spinal cord
injury (SCI) are still challenging. Several experimental therapeutic strategies have been …
injury (SCI) are still challenging. Several experimental therapeutic strategies have been …
Mesenchymal stem cells transplanted into spinal cord injury adopt immune cell-like characteristics
R Hakim, R Covacu, V Zachariadis, A Frostell… - Stem Cell Research & …, 2019 - Springer
Abstract Background Mesenchymal stem cells (MSCs) and their cellular response to various
stimuli have been characterized in great detail in culture conditions. In contrast, the cellular …
stimuli have been characterized in great detail in culture conditions. In contrast, the cellular …