[HTML][HTML] Molecular mechanisms and biological functions of siRNA

H Dana, GM Chalbatani… - … journal of biomedical …, 2017 - ncbi.nlm.nih.gov
One of the most important advances in biology has been the discovery that siRNA (small
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …

Production and clinical development of nanoparticles for gene delivery

J Chen, Z Guo, H Tian, X Chen - Molecular Therapy Methods & Clinical …, 2016 - cell.com
Gene therapy is a promising strategy for specific treatment of numerous gene-associated
human diseases by intentionally altering the gene expression in pathological cells. A …

Photoresponsive nanoparticles for drug delivery

AY Rwei, W Wang, DS Kohane - Nano today, 2015 - Elsevier
Externally triggerable drug delivery systems provide a strategy for the delivery of therapeutic
agents preferentially to a target site, presenting the ability to enhance therapeutic efficacy …

Cell-penetrating peptides as versatile vehicles for oligonucleotide delivery

H Margus, K Padari, M Pooga - Molecular Therapy, 2012 - cell.com
Short regulatory oligonucleotides (ONs) have a great therapeutic potential for the
modulation of gene expression due to their high specificity and low toxicity. The major …

Nanoparticles escaping RES and endosome: challenges for siRNA delivery for cancer therapy

S Guo, L Huang - Journal of Nanomaterials, 2011 - Wiley Online Library
Small interfering RNAs (siRNAs) technology has emerged as a promising potential
treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential …

Multifunctional cationic lipid-based nanoparticles facilitate endosomal escape and reduction-triggered cytosolic siRNA release

M Gujrati, A Malamas, T Shin, E Jin, Y Sun… - Molecular …, 2014 - ACS Publications
Small interfering RNA (siRNA) has garnered much attention in recent years as a promising
avenue for cancer gene therapy due to its ability to silence disease-related genes. Effective …

Recent developments in nanoparticle‐based siRNA delivery for cancer therapy

JM Lee, TJ Yoon, YS Cho - BioMed research international, 2013 - Wiley Online Library
RNA interference (RNAi) is a gene regulation mechanism initiated by RNA molecules that
enables sequence‐specific gene silencing by promoting degradation of specific mRNAs …

Multiple Morphologies of PAA-b-PSt Assemblies throughout RAFT Dispersion Polymerization of Styrene with PAA Macro-CTA

WD He, XL Sun, WM Wan, CY Pan - Macromolecules, 2011 - ACS Publications
The assembly behavior of diblock copolymers in solution can be modulated by block length,
block ratio, solvent properties, and preparation route. Different assembly morphologies such …

[HTML][HTML] Nanoparticles as drug delivery systems in cancer medicine: emphasis on RNAi-containing nanoliposomes

MR Díaz, PE Vivas-Mejia - Pharmaceuticals, 2013 - mdpi.com
Nanomedicine is a growing research field dealing with the creation and manipulation of
materials at a nanometer scale for the better treatment, diagnosis and imaging of diseases …

Delivery strategies and potential targets for siRNA in major cancer types

SJ Lee, MJ Kim, IC Kwon, TM Roberts - Advanced drug delivery reviews, 2016 - Elsevier
Small interfering RNA (siRNA) has gained attention as a potential therapeutic reagent due to
its ability to inhibit specific genes in many genetic diseases. For many years, studies of …