[HTML][HTML] Molecular mechanisms and biological functions of siRNA
H Dana, GM Chalbatani… - … journal of biomedical …, 2017 - ncbi.nlm.nih.gov
One of the most important advances in biology has been the discovery that siRNA (small
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …
Production and clinical development of nanoparticles for gene delivery
Gene therapy is a promising strategy for specific treatment of numerous gene-associated
human diseases by intentionally altering the gene expression in pathological cells. A …
human diseases by intentionally altering the gene expression in pathological cells. A …
Photoresponsive nanoparticles for drug delivery
Externally triggerable drug delivery systems provide a strategy for the delivery of therapeutic
agents preferentially to a target site, presenting the ability to enhance therapeutic efficacy …
agents preferentially to a target site, presenting the ability to enhance therapeutic efficacy …
Cell-penetrating peptides as versatile vehicles for oligonucleotide delivery
Short regulatory oligonucleotides (ONs) have a great therapeutic potential for the
modulation of gene expression due to their high specificity and low toxicity. The major …
modulation of gene expression due to their high specificity and low toxicity. The major …
Nanoparticles escaping RES and endosome: challenges for siRNA delivery for cancer therapy
Small interfering RNAs (siRNAs) technology has emerged as a promising potential
treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential …
treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential …
Multifunctional cationic lipid-based nanoparticles facilitate endosomal escape and reduction-triggered cytosolic siRNA release
Small interfering RNA (siRNA) has garnered much attention in recent years as a promising
avenue for cancer gene therapy due to its ability to silence disease-related genes. Effective …
avenue for cancer gene therapy due to its ability to silence disease-related genes. Effective …
Recent developments in nanoparticle‐based siRNA delivery for cancer therapy
JM Lee, TJ Yoon, YS Cho - BioMed research international, 2013 - Wiley Online Library
RNA interference (RNAi) is a gene regulation mechanism initiated by RNA molecules that
enables sequence‐specific gene silencing by promoting degradation of specific mRNAs …
enables sequence‐specific gene silencing by promoting degradation of specific mRNAs …
Multiple Morphologies of PAA-b-PSt Assemblies throughout RAFT Dispersion Polymerization of Styrene with PAA Macro-CTA
WD He, XL Sun, WM Wan, CY Pan - Macromolecules, 2011 - ACS Publications
The assembly behavior of diblock copolymers in solution can be modulated by block length,
block ratio, solvent properties, and preparation route. Different assembly morphologies such …
block ratio, solvent properties, and preparation route. Different assembly morphologies such …
[HTML][HTML] Nanoparticles as drug delivery systems in cancer medicine: emphasis on RNAi-containing nanoliposomes
MR Díaz, PE Vivas-Mejia - Pharmaceuticals, 2013 - mdpi.com
Nanomedicine is a growing research field dealing with the creation and manipulation of
materials at a nanometer scale for the better treatment, diagnosis and imaging of diseases …
materials at a nanometer scale for the better treatment, diagnosis and imaging of diseases …
Delivery strategies and potential targets for siRNA in major cancer types
SJ Lee, MJ Kim, IC Kwon, TM Roberts - Advanced drug delivery reviews, 2016 - Elsevier
Small interfering RNA (siRNA) has gained attention as a potential therapeutic reagent due to
its ability to inhibit specific genes in many genetic diseases. For many years, studies of …
its ability to inhibit specific genes in many genetic diseases. For many years, studies of …