Over the past decade, RNA interference (RNAi) has been ubiquitously utilized to study
biological function in vitro; however, limitations were associated with its utility in vivo. More …

RNA interference (RNAi) is a powerful method used for gene expression regulation. The
increasing knowledge about the molecular mechanism of this phenomenon creates new …

Introduction: RNA interference (RNAi) is a powerful mechanism for gene silencing with the
potential to greatly impact the development of new therapies for many human diseases …

There has been a paradigm shift in our understanding of how protein regulation occurs
within mammalian cells in the last 15 years. Our current understanding is that small …

Poor cellular uptake, rapid degradation in the presence of serum, and inefficient transfection
are some of the major barriers in achieving therapeutic efficacy of naked small interfering …

Nowadays, biodegradable nanoscale preparations such as liposomes, micelles,
nanoparticles (NPs), and solid lipid nanoparticles (SLN) have attracted increasing attention …

To limit cytotoxicity of anticancer drugs against healthy cells, an appropriate carrier should
be synthesized to deliver the drug to the tumor tissue only. A good solution is to anchor a …

Advances in nanotechnology opened up new horizons in the field of cancer research.
Nanoparticles made of various organic and inorganic materials and with different optical …

Semaphorin 4d (Sema4d) has been proposed as a novel target gene for the treatment of
osteoporosis. Recently, we fabricated a site-specific bone-targeting system from polymeric …

The discovery of RNA interference (RNAi) as a naturally occurring mechanism for gene
knockdown has attracted considerable attention toward the use of small interfering RNAs …