Background Reactive oxygen species (ROS) are implicated in cancer therapy and as drivers
of microenvironmental tumour cell adaptations. Medical gas plasma is a multi-ROS …

Numerous trials have been launched over the prior decade examining the safety and
efficacy of therapy de-escalation in human papillomavirus (HPV)-associated oropharyngeal …

Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a
dismal patient prognosis. Despite significant advances in treatment modalities, the five-year …

An important challenge in the field of cancer is finding the balance between delivering
effective treatments and avoiding adverse effects and financial toxicity caused by innovative …

Simple Summary Head and neck cancer belongs to the six most common cancers
worldwide, with the majority of cases being associated with chronic alcohol and/or tobacco …

AbstractPurpose: Systemic, immune, and target therapies are growing in use in the
management of metastatic cancers. The aim of this review was to describe up-to-date …

MAPK pathway mutations affect one-fifth of head and neck squamous cell carcinoma
(HNSCC). Unexpectedly, MAPK pathway aberrations are associated with remarkably long …

Purpose Activation of the PI3K/mTOR signaling pathway is common in head and neck
squamous cell carcinoma (HNSCC). BYL719 is an α-specific PI3K inhibitor that is synergistic …

Chemoradiotherapy as an alternative to surgery can be offered to patients affected by loco-
regionally advanced head and neck cancer (HNC). Induction chemotherapy is a valid …

Patients with human papillomavirus‐(HPV‐) related oropharyngeal squamous cell
carcinoma (OPSCC) have a better prognosis than HPV‐negative OPSCC when treated with …