Analyses of steroid receptors are important for understanding molecular details of
transcriptional control, as well as providing insight as to how an individual transacting factor …

Over the past 5 yr, we have examined some of the sharpest edges of the pathology of aging.
We have studied the capacity of aged organisms to respond appropriately to stress and the …

Corticotropin-releasing hormone (CRH) plays a central role in the regulation of the
hypothalamic-pituitary-adrenal (HPA)-axis, ie, the final common pathway in the stress …

We have used Golgi-impregnated tissue to demonstrate that exposure to excess
glucocorticoids alters dendritic morphology in a specific population of neurons in the adult …

In more than 95% of mammalian species, males provide little direct investment in the well-
being of their offspring. Humans are one notable exception to this pattern and, to date, the …

Repeated restraint stress of rats for 21 days causes atrophy of apical dendrites of
hippocampal CA3c pyramidal neurons. This effect is mimicked by daily corticosterone …

Previous brain imaging studies have demonstrated responses to tactile and auditory stimuli
in visual cortex of blind subjects, suggesting that removal of one sensory modality leads to …

An extensive literature demonstrates that glucocorticoids (GCs), the adrenal steroids
secreted during stress, can have a broad range of deleterious effects in the brain. The …

The hippocampus, a limbic structure important in learning and memory, is particularly
sensitive to chronic stress and to glucocorticoids. While glucocorticoids are essential for an …

Stress can have lasting effects on the brain and behavior. Delineating the impact of stress on
the developing brain is fundamental for understanding mechanisms through which stress …