Psychostimulants, including amphetamines and methylphenidate, are first-line
pharmacotherapies for individuals with attention-deficit/hyperactivity disorder (ADHD). This …

General anesthesia is characterized by loss of consciousness, amnesia, analgesia, and
immobility. Important molecular targets of general anesthetics have been identified, but the …

The human body cycles through two phases of sleep,(1) rapid eye movement (REM) and (2)
non-rapid eye movement (NREM) sleep, which is further divided into three stages, N1-N3 …

The current report provides an updated review of sleep disturbance in posttraumatic stress
disorder and anxiety-related disorders. First, this review provides a summary description of …

Sleep is a vital function of the nervous system that contributes to brain and bodily
homeostasis, energy levels, cognitive ability, and other key functions of a variety of …

Highlights•Neural oscillations provide a framework for comparing general anesthesia and
sleep.•Anesthetic drugs do not induce the physiological neural oscillations of sleep.•Non …

Insomnia is a highly prevalent condition associated with significant morbidity, reduction in
quality of life, and increase in healthcare costs, and is a risk factor for multiple physical and …

Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation method
widely used by neuroscientists and clinicians for research and therapeutic purposes. tDCS …

Patients with depression almost inevitably exhibit abnormalities in sleep, such as shortened
latency to enter rapid eye movement (REM) sleep and decrease in electroencephalogram …

Background Mevidalen is a selective positive allosteric modulator (PAM) of the dopamine
D1 receptor subtype. Objective To assess the safety and efficacy of mevidalen for treatment …