Male reproduction is a complex process, and numerous medical conditions have the
potential to alter spermatogenesis. In addition, male factor infertility may be a biomarker for …

The steroidogenic cells in the testicle, Leydig cells, located in the interstitial compartment,
play a vital role in male reproductive tract development, maintenance of proper …

Background Present knowledge on the impact of varicoceles on testicular function is largely
based on studies of subfertile and infertile men, making it difficult to extrapolate the impact of …

Abstract Purpose Infertility affects 15–20% of couples and male factors are present in about
half of the cases. For many aspects related to the diagnostic and therapeutic approach of …

The testicular dysgenesis syndrome (TDS) hypothesis, which proposes that common
reproductive disorders of newborn and adult human males may have a common fetal origin …

Background Some evidence suggests that infertile men, who are at increased risk for
hypogonadism, metabolic derangements, and osteoporosis, have higher long-term …

Importance Diet may play a role in testicular function, but data on how adherence to different
diet patterns influences human testicular function are scarce. Objective To determine …

Polybrominated diphenyl ethers (PBDEs) are a widely used class of brominated flame
retardants. Exposure to PBDEs could induce testicular damage in mammals, but the effects …

Leydig cells are the major testosterone-producing cells of the male reproductive system, and
damage to these cells can impair fertility of men. Bisphenol A (BPA) is one of the chemicals …

Non-steroidal anti-inflammatory drugs (NSAIDs) and 17α-ethinylestradiol (EE2) are
extensively used in human and veterinary medicine. Due to their partial removal by …