Treg cells in health and autoimmune diseases: New insights from single cell analysis

C Scheinecker, L Göschl, M Bonelli - Journal of autoimmunity, 2020 - Elsevier
Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

Treg cells in autoimmunity: from identification to Treg-based therapies

L Göschl, C Scheinecker, M Bonelli - Seminars in immunopathology, 2019 - Springer
Regulatory (Treg) cells are key regulators of inflammation and important for immune
tolerance and homeostasis. A major progress has been made in the identification and …

Human FoxP3+ regulatory T cells in systemic autoimmune diseases

M Miyara, G Gorochov, M Ehrenstein, L Musset… - Autoimmunity …, 2011 - Elsevier
Since the characterization of CD4+ CD25+ regulatory T (Treg) cells in mice, significant
progress has been made in the definitions of the phenotype and the function of human Treg …

Elevated Th17 cells are accompanied by FoxP3+ Treg cells decrease in patients with lupus nephritis

Q Xing, B Wang, H Su, J Cui, J Li - Rheumatology international, 2012 - Springer
To investigate the variations of T-helper 17 (Th17) and regulatory T (Treg) cells in patients
with lupus nephritis (LN), a total of 60 systemic lupus erythematosus patients and 28 healthy …

T cells and IL-17 in lupus nephritis

T Koga, K Ichinose, GC Tsokos - Clinical immunology, 2017 - Elsevier
Systemic lupus erythematosus (SLE) is a complicated autoimmune disorder characterized
by autoantibodies production, immune complex formation, and immune dysregulation …

The regulatory T cell in active systemic lupus erythematosus patients: a systemic review and meta-analysis

W Li, C Deng, H Yang, G Wang - Frontiers in immunology, 2019 - frontiersin.org
Background: Regulatory T cells (Tregs) researches in systemic lupus erythematosus (SLE)
have floundered over the years, reports on the numbers and function of Tregs in SLE …

T cells as a therapeutic target in SLE

D Comte, MP Karampetsou, GC Tsokos - Lupus, 2015 - journals.sagepub.com
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by
a loss of tolerance to multiple endogenous antigens. SLE etiology remains largely unknown …

[HTML][HTML] Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis

KM Chavele, MR Ehrenstein - FEBS letters, 2011 - Elsevier
Regulatory T-cells (Tregs) are the guardians of peripheral tolerance acting to prevent
autoimmune diseases such as systemic lupus erythomatosus (SLE) and rheumatoid arthritis …

The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target

T Koga, K Ichinose, A Kawakami… - Expert review of clinical …, 2019 - Taylor & Francis
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized
by autoantibodies production and immune complex deposition with systemic clinical …

Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus

T Koga, K Ichinose, M Mizui, JC Crispín… - The Journal of …, 2012 - journals.aai.org
The activity of calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased in T
cells from patients with systemic lupus erythematosus (SLE) and has been shown to reduce …