Ferroptosis has recently been demonstrated to be a novel regulated non-apoptotic cell
death characterized by iron-dependence and the accumulation of lipid peroxidation that …

Obesity is an excessive adipose tissue accumulation that may have detrimental effects on
health. Particularly, childhood obesity has become one of the main public health problems in …

Ferroptosis is a regulated form of cell death induced by iron (Fe)-dependent lipid
peroxidation. At present, the underlying molecular mechanisms remain elusive. Herein, we …

The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type
II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in …

Nonalcoholic fatty liver disease (NAFLD) is a chronic condition affecting one quarter of the
global population. Although primarily linked to obesity and metabolic syndrome …

Iron is the most abundant mineral in the human body and plays essential roles in sustaining
life, such as the transport of oxygen to systemic organs. The Fenton reaction is the reaction …

Stroke is a common and serious nervous system disease caused by the rupture or blockage
of the cardiovascular system. It causes millions of deaths and disabilities every year, which …

Iron is an essential transition metal for numerous biologic processes in mammals. Iron
metabolism is regulated via several coordination mechanisms including absorption …

Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in
a hostile environment characterized by nutrient deprivation, poor vascularization and …

Essential trace metals like zinc (Zn), iron (Fe), and copper (Cu) play an important
physiological role in the metabolomics and healthy functioning of body organs, including the …