Ribosome-mediated synthesis of proteins, us-ing messenger ribonucleic acid (mRNA) as
the template, is one of the hallmarks of earthly life forms. It is not surprising that the cellular …

Gene expression can be controlled by changing the half-lifes of specific mRNAs in response
to intracellular events or to extracellular stimuli. Many experiments suggest that mRNA …

When the first edition of this book was published in 1950, it set out to present an elementary
outline of the state of knowledge of nucleic acid biochemistry at that time and it was the first …

Using an in vitro mRNA decay system, we investigated how poly (A) and its associated poly
(A)-binding protein (PABP) affect mRNA stability. Cell extracts used in the decay reactions …

From the date of its discovery in 1970, the 3'poly (A) tail of eukaryotic mRNA has taken on
the character of a structure in search of a function. Candidate functions favored in those far …

Synthetic RNAs coding for chicken lysozyme, calf preprochymozin and Xenopus globin were
transcribed in vitro using Sp6 RNA polymerase. The effects of capping and adding a poly (A) …

The early steps in the degradation of human c-myc mRNA were investigated, using a
previously described cell-free mRNA decay system. The first detectable step was poly (A) …

The occurrence of poly (A) as a component of eukaryotic messenger RNA has been known
for about 10 years, but the role of this sequence is still something of a mystery. The poly (A) …

Biological polyadenylation, first recognized as an enzymatic activity, remained an orphan
enzyme until poly A sequences were found on the 3′ ends of eukaryotic mRNAs. Their …

The actual formation of a prokaryotic messenger RNA (mRNA) is a relatively simple process
involving mainly the transcription of an ap propriate gene by RNA polymerase. In most …