Genetic modulation: future trends toward graft optimization during machine perfusion

S Stimmeder, B Leber, R Sucher, P Stiegler - Transplantation, 2024 - journals.lww.com
Dynamic preservation methods such as normothermic, subnormothermic, and hypothermic
machine perfusion circuits have emerged as viable alternatives to conventional static cold …

Progress in preservation of intestinal grafts by oxygenated hypothermic machine perfusion

S Yang, W Hou, L Liu - Transplantation Reviews, 2023 - Elsevier
Intestine transplantation (IT) is a critical treatment strategy for irreversible intestinal failure.
Among all abdominal solid organ transplants, the intestine was the most vulnerable to …

Effect of Subnormothermic Machine Perfusion on the Preservation of Vascularized Composite Allografts After Prolonged Warm Ischemia

L Charlès, IF von Reiterdank, HH Lancia… - …, 2024 - journals.lww.com
Background. Warm ischemia time (WIT) and ischemia–reperfusion injury are limiting factors
for vascularized composite allograft (VCA) transplantation. Subnormothermic machine …

Tissue Injury Protection: The Other Face of Anticoagulant Treatments in the Context of Ischemia and Reperfusion Injury with a Focus on Transplantation

J Carré, T Kerforne, T Hauet, L Macchi - International Journal of …, 2023 - mdpi.com
Organ transplantation has enhanced the length and quality of life of patients suffering from
life-threatening organ failure. Donors deceased after brain death (DBDDs) have been a …

Normothermic machine perfusion for liver transplantation: current state and future directions

J Lindemann, J Yu, MBM Doyle - Current Opinion in Organ …, 2024 - journals.lww.com
NMP has resulted in increased organ utilization from marginal donors with acceptable
outcomes. The added flexibility of prolonged organ storage times has the potential to …

Current opinion: advances in machine perfusion and preservation of vascularized composite allografts–will time still matter?

TE Muss, AH Loftin, BC Oh… - Current opinion in organ …, 2023 - journals.lww.com
Current and emerging machine perfusion and preservation technologies in VCA have great
promise to transform the field of reconstructive transplantation, as every extra hour of CIT …

[HTML][HTML] Exploring Preservation Modalities in a Split Human Pancreas Model to Investigate the Effect on the Islet Isolation Outcomes

A Buemi, NI Mourad, C Bouzin, A Devresse… - Transplantation …, 2024 - journals.lww.com
Background. In islet transplantation, the use of dynamic hypothermic preservation
techniques is a current challenge. This study compares the efficacy of 3 pancreas …

Neither Ethical nor Prudent: Why Not to Choose Normothermic Regional Perfusion

A Omelianchuk, AM Capron, LF Ross… - Hastings Center …, 2024 - Wiley Online Library
In transplant medicine, the use of normothermic regional perfusion (NRP) in donation after
circulatory determination of death raises ethical difficulties. NRP is objectionable because it …

Twenty-four-hour Normothermic Ex Vivo Heart Perfusion With Low Flow Functional Assessment in an Adult Porcine Model

BL Spencer, SK Wilhelm, KA Urrea… - …, 2024 - journals.lww.com
Background. Cold static storage and normothermic ex vivo heart perfusion are routinely
limited to 6 h. This report describes intermittent left atrial (LA) perfusion that allows cardiac …

[PDF][PDF] Moving Boundaries for Improving Organ Transplant Availability

J Chapman - Experimental and Clinical Transplantation, 2023 - ectrx.org
This brief overview is designed to address the options for increasing organ transplant rates
to between 100 and 120 transplanted organs per million population globally. The focus of …