Transcription factors (TFs) are well-established key factors orchestrating gene transcription,
and RNA-binding proteins (RBPs) are mainly thought to participate in post-transcriptional …

Control of pre-mRNA splicing is a critical part of the eukaryotic gene expression process.
Extensive evidence indicates that transcription and splicing are spatiotemporally …

There are numerous data suggesting that two key steps in gene expression-transcription
and splicing influence each other closely. For a long time it was known that chromatin …

The splicing machinery associates with genes to facilitate efficient cotranscriptional mRNA
processing. We have mapped these associations by genome localization analysis to …

Transcription, RNA processing, and chromatin‐related factors all interact with RNA
polymerase II (Pol II) to ensure proper timing and coordination of transcription and co …

Eukaryotic gene expression requires the cumulative activity of multiple molecular machines
to synthesize and process newly transcribed pre-messenger RNA. Introns, the noncoding …

Cells respond to many external stimuli by modulating gene expression. A key step in this
regulation is the control of transcription, which determines the concentrations of pre-mRNA …

Splicing of RNA polymerase II transcripts is a crucial step in gene expression and a key
generator of mRNA diversity. Splicing and transcription have generally been studied in …

Alternative splicing affects more than 90% of human genes. Coupling between transcription
and splicing has become crucial in the complex network underlying alternative splicing …

We investigated whether a continuous transcript is necessary for co-transcriptional pre-
mRNA processing. Cutting an intron with the fast-cleaving hepatitis δ ribozyme, but not the …