The RNA metabolism involves different steps from transcription to translation and decay of
messenger RNAs (mRNAs), and those different layers are each regulated and …

Splicing occurs co-transcriptionally, but relative rates of splicing and transcription that might
reveal mechanisms of their coordinated control have remained mysterious. Now, Carrillo …

Most eukaryotic genes are expressed as precursor messenger RNAs (pre-mRNAs) that are
converted to mRNAs by splicing, an essential step of gene expression. Splicing is catalyzed …

There is little quantitative information regarding how much splicing occurs co-
transcriptionally in higher eukaryotes, and it remains unclear where precisely splicing occurs …

After the discovery of RNase P1 (Chapter 9) and the Group I2 (Chapter 10) intron ribozymes,
both of which are comparatively large and complex catalytic RNAs, the identification of the …

The catalytic removal of introns via pre-mRNA splicing during pre-mRNA processing is an
essential component of eukaryotic gene expression. Splicing is a pervasive and highly …

Splicing is an essential step in gene expression, and modulators often target the process of
splicing to regulate sets of genes. Furthermore, splicing is intricately coordinated with other …

Human genes contain many long introns with degenerate sequence information at splice
sites, requiring sophisticated mechanisms to locate and coordinate the excision of multiple …

In my thesis, I focused on several underexplored areas of RNA splicing regulation. In the first
part, I analyzed how chromatin and transcription regulatory elements change pre-mRNA …

There is increasing evidence from yeast to humans that splicing is mainly a co-
transcriptional process, and it is becoming well established that splicing, transcription and …