Mechanisms of airway epithelial injury and abnormal repair in asthma and COPD
KL Raby, C Michaeloudes, J Tonkin, KF Chung… - Frontiers in …, 2023 - frontiersin.org
The airway epithelium comprises of different cell types and acts as a physical barrier
preventing pathogens, including inhaled particles and microbes, from entering the lungs …
preventing pathogens, including inhaled particles and microbes, from entering the lungs …
Novel anti-inflammatory approaches to COPD
M Cazzola, NA Hanania, CP Page… - International journal of …, 2023 - Taylor & Francis
Airway inflammation, driven by different types of inflammatory cells and mediators, plays a
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …
Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway
X Wu, Y Jiang, R Li, Y Xia, F Li, M Zhao, G Li… - Cell Death & …, 2023 - nature.com
Pathogenesis exploration and timely intervention of lung injury is quite necessary as it has
harmed human health worldwide for years. Ficolin B (Fcn B) is a recognition molecule that …
harmed human health worldwide for years. Ficolin B (Fcn B) is a recognition molecule that …
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation
W Ouyang, S Wang, D Yan, J Wu, Y Zhang… - … and Targeted Therapy, 2023 - nature.com
The innate immune response is the main pathophysiological process of ocular surface
diseases exposed to multiple environmental stresses. The epithelium is central to the innate …
diseases exposed to multiple environmental stresses. The epithelium is central to the innate …
Autophagy/mitophagy in airway diseases: impact of oxidative stress on epithelial cells
GD Albano, AM Montalbano, R Gagliardo, M Profita - Biomolecules, 2023 - mdpi.com
Autophagy is the key process by which the cell degrades parts of itself within the lysosomes.
It maintains cell survival and homeostasis by removing molecules (particularly proteins) …
It maintains cell survival and homeostasis by removing molecules (particularly proteins) …
Bronchial epithelial and airway smooth muscle cell interactions in health and disease
R Abohalaka - Heliyon, 2023 - cell.com
Chronic pulmonary diseases such as asthma, COPD, and Idiopathic pulmonary fibrosis are
significant causes of mortality and morbidity worldwide. Currently, there is no radical …
significant causes of mortality and morbidity worldwide. Currently, there is no radical …
The immune mechanism of the nasal epithelium in COVID-19–related olfactory dysfunction
S Chen, S Wang - Frontiers in Immunology, 2023 - frontiersin.org
During the first waves of the coronavirus disease 2019 (COVID-19) pandemic caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, olfactory …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, olfactory …
3D Airway Epithelial–Fibroblast Biomimetic Microfluidic Platform to Unravel Engineered Nanoparticle-Induced Acute Stress Responses as Exposome Determinants
MKH Lee, HK Lim, C Su, JYC Koh… - Environmental …, 2023 - ACS Publications
Insights into how biological systems respond to high-and low-dose acute environmental
stressors are a fundamental aspect of exposome research. However, studying the impact of …
stressors are a fundamental aspect of exposome research. However, studying the impact of …
Blood immunophenotypes of idiopathic pulmonary fibrosis: relationship with Disease Severity and Progression
N Mendoza, S Casas-Recasens, N Olvera… - International journal of …, 2023 - mdpi.com
(1) The role of the immune response in the pathogenesis of idiopathic pulmonary fibrosis
(IPF) remains controversial. We hypothesized that peripheral blood immune phenotypes will …
(IPF) remains controversial. We hypothesized that peripheral blood immune phenotypes will …
Neutrophils play a major role in the destruction of the olfactory epithelium during SARS-CoV-2 infection in hamsters
C Bourgon, AS Albin, O Ando-Grard… - Cellular and Molecular …, 2022 - Springer
The loss of smell (anosmia) related to SARS-CoV-2 infection is one of the most common
symptoms of COVID-19. Olfaction starts in the olfactory epithelium mainly composed of …
symptoms of COVID-19. Olfaction starts in the olfactory epithelium mainly composed of …