Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

Heparan sulfate proteoglycans (HSPGs) encompass a group of glycoproteins composed of
unbranched negatively charged heparan sulfate (HS) chains covalently attached to a core …

Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic
cardiomyopathy (ACM) convey high risks for the development of heart failure through …

Glycosylation is essential to brain development and function, but prior studies have often
been limited to a single analytical technique and excluded region-and sex-specific analyses …

In the last decade, tremendous progress has been made in understanding the biology of
microglia–ie the fascinating immigrated resident immune cell population of the central …

Heparan sulfate proteoglycans (HSPGs) are complex carbohydrate-modified proteins
ubiquitously expressed on cell surfaces, extracellular matrix and basement membrane of …

In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an
intriguing subject of study for their complex structural characteristics, their finely regulated …

The extracellular matrix (ECM) plays diverse roles in several physiological and pathological
conditions. In the brain, the ECM is unique both in its composition and in functions …

The orderly development of the nervous system is characterized by phases of cell
proliferation and differentiation, neural migration, axonal outgrowth and synapse formation …

In this comprehensive review, we will dissect the impact of research on proteoglycans
focusing on recent developments involved in their synthesis, degradation, and interactions …