The worldwide increase in the incidence of diabetes, the increase in type 2 diabetes in
women at reproductive ages, and the cross-generation of the intrauterine programming of …

The fetal origins of adult disease (FOAD) hypothesis holds that events during early
development have a profound impact on one's risk for the development of future adult …

Peroxisome proliferator-activated receptors (PPARα, PPARδ and PPARγ) are ligand-
activated transcription factors that regulate metabolic, anti-inflammatory and developmental …

Birth defects resulting from diabetic pregnancy are associated with apoptosis of a critical
mass of progenitor cells early during the formation of the affected organ (s). Insufficient …

An adverse intrauterine programming occurs in diabetes and obesity as the consequence of
an adverse maternal environment that affects the appropriate fetoplacental development …

The melanocortin-4 receptor (MC4R) is a critical regulator of energy homeostasis and has
emerged as a premier target for obesity treatment. Numerous mutations in transmembrane …

In gestational diabetes mellitus (GDM) pregnancies, a compromised fetal liver may impact
offspring's metabolic health. Here, we aimed to address prooxidant, proinflammatory and …

Aberrant arachidonic acid and nitric oxide (NO) metabolic pathways are involved in diabetic
embryopathy. Previous works have found diminished concentrations of PGE2 and PGI2 in …

The aim of this study was to evaluate the paternal programming of sex-dependent
alterations in fetoplacental growth and placental lipid metabolism regulated by peroxisome …

Background Maternal diabetes is associated with morphological placental abnormalities
and foeto‐placental impairments. These alterations are linked with a dysregulation of the …