Clostridial C3 toxins target monocytes/macrophages and modulate their functions
H Barth, S Fischer, A Möglich, C Förtsch - Frontiers in Immunology, 2015 - frontiersin.org
The C3 enzymes from Clostridium (C.) botulinum (C3bot) and Clostridium limosum (C3lim)
are single chain protein toxins of about 25 kDa that mono-ADP-ribosylate Rho-A,-B, and-C …
are single chain protein toxins of about 25 kDa that mono-ADP-ribosylate Rho-A,-B, and-C …
Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins
I Just, F Hofmann, H Genth, R Gerhard - International journal of medical …, 2001 - Elsevier
The Rho GTPases, which belong to the Ras superfamily of low-molecular-mass GTP-
binding proteins, are the preferred intracellular targets of bacterial protein toxins. The Rho …
binding proteins, are the preferred intracellular targets of bacterial protein toxins. The Rho …
Selective and specific internalization of clostridial C3 ADP‐ribosyltransferases into macrophages and monocytes
J Fahrer, J Kuban, K Heine, G Rupps… - Cellular …, 2010 - Wiley Online Library
The C3 transferases from Clostridium botulinum (C3bot) and Clostridium limosum (C3lim)
mono‐ADP‐ribosylate and thereby inactivate RhoA,‐B and‐C of eukaryotic cells. Due to …
mono‐ADP‐ribosylate and thereby inactivate RhoA,‐B and‐C of eukaryotic cells. Due to …
Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo
T Martin, A Möglich, I Felix, C Förtsch, A Rittlinger… - Archives of …, 2018 - Springer
Bacterial protein toxins became valuable molecular tools for the targeted modulation of cell
functions in experimental pharmacology and attractive therapeutics because of their potent …
functions in experimental pharmacology and attractive therapeutics because of their potent …
Clostridium Botulinum C3 Exoenzyme and C3-Like Transferases
K Aktories, H Barth, I Just - Bacterial Protein Toxins, 2000 - Springer
Clostridium botulinum adenosine diphosphate (ADP)—ribosyltransferase C3 was the first
bacterial exoenzyme/toxin found to act on small guanosine triphosphate (GTP) ases of the …
bacterial exoenzyme/toxin found to act on small guanosine triphosphate (GTP) ases of the …
[PDF][PDF] 16. Toxintyping by phenotypic and genetic assays
M Popoff, RW Titball - Genus Clostridium, 2006 - Citeseer
Glucosylating toxins are also referred to as large clostridial toxins (Table 16.1) and are
single chain proteins ranging in size from 250 to 300 kDa. The large clostridial toxin family …
single chain proteins ranging in size from 250 to 300 kDa. The large clostridial toxin family …