Kidney fibrosis: from mechanisms to therapeutic medicines

R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

The fibrogenic niche in kidney fibrosis: components and mechanisms

L Li, H Fu, Y Liu - Nature Reviews Nephrology, 2022 - nature.com
Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

The global burden of chronic kidney disease

P Cockwell, LA Fisher - The Lancet, 2020 - thelancet.com
Surgical delays cannot be avoided in patients unfit for surgery at the time of admission
because of poor health status, severe comorbidities, or previous medication. Some …

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models

F Ren, A Aliper, J Chen, H Zhao, S Rao, C Kuppe… - Nature …, 2024 - nature.com
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …

Health inequities and the inappropriate use of race in nephrology

ND Eneanya, LE Boulware, J Tsai, MA Bruce… - Nature Reviews …, 2022 - nature.com
Chronic kidney disease is an important clinical condition beset with racial and ethnic
disparities that are associated with social inequities. Many medical schools and health …

Uremic toxins in the progression of chronic kidney disease and cardiovascular disease: mechanisms and therapeutic targets

YJ Lim, NA Sidor, NC Tonial, A Che, BL Urquhart - Toxins, 2021 - mdpi.com
Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …

Design of the COmbinatioN effect of FInerenone anD EmpaglifloziN in participants with chronic kidney disease and type 2 diabetes using a UACR Endpoint study …

JB Green, AK Mottl, G Bakris… - Nephrology Dialysis …, 2023 - academic.oup.com
Background Despite available interventions, people with type 2 diabetes (T2D) remain at
risk of chronic kidney disease (CKD). Finerenone, a potent and selective nonsteroidal …

A deep neural network for early detection and prediction of chronic kidney disease

V Singh, VK Asari, R Rajasekaran - Diagnostics, 2022 - mdpi.com
Diabetes and high blood pressure are the primary causes of Chronic Kidney Disease (CKD).
Glomerular Filtration Rate (GFR) and kidney damage markers are used by researchers …

[HTML][HTML] Ten things to know about ten cardiovascular disease risk factors

HE Bays, PR Taub, E Epstein, ED Michos… - American journal of …, 2021 - Elsevier
Given rapid advancements in medical science, it is often challenging for the busy clinician to
remain up-to-date on the fundamental and multifaceted aspects of preventive cardiology and …

Transforming growth factor-β signaling: from tissue fibrosis to therapeutic opportunities

LL Ren, XJ Li, TT Duan, ZH Li, JZ Yang… - Chemico-biological …, 2023 - Elsevier
Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …