Kidney fibrosis: from mechanisms to therapeutic medicines
R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
The fibrogenic niche in kidney fibrosis: components and mechanisms
L Li, H Fu, Y Liu - Nature Reviews Nephrology, 2022 - nature.com
Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …
The global burden of chronic kidney disease
P Cockwell, LA Fisher - The Lancet, 2020 - thelancet.com
Surgical delays cannot be avoided in patients unfit for surgery at the time of admission
because of poor health status, severe comorbidities, or previous medication. Some …
because of poor health status, severe comorbidities, or previous medication. Some …
A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
Health inequities and the inappropriate use of race in nephrology
Chronic kidney disease is an important clinical condition beset with racial and ethnic
disparities that are associated with social inequities. Many medical schools and health …
disparities that are associated with social inequities. Many medical schools and health …
Uremic toxins in the progression of chronic kidney disease and cardiovascular disease: mechanisms and therapeutic targets
YJ Lim, NA Sidor, NC Tonial, A Che, BL Urquhart - Toxins, 2021 - mdpi.com
Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …
Design of the COmbinatioN effect of FInerenone anD EmpaglifloziN in participants with chronic kidney disease and type 2 diabetes using a UACR Endpoint study …
Background Despite available interventions, people with type 2 diabetes (T2D) remain at
risk of chronic kidney disease (CKD). Finerenone, a potent and selective nonsteroidal …
risk of chronic kidney disease (CKD). Finerenone, a potent and selective nonsteroidal …
A deep neural network for early detection and prediction of chronic kidney disease
Diabetes and high blood pressure are the primary causes of Chronic Kidney Disease (CKD).
Glomerular Filtration Rate (GFR) and kidney damage markers are used by researchers …
Glomerular Filtration Rate (GFR) and kidney damage markers are used by researchers …
[HTML][HTML] Ten things to know about ten cardiovascular disease risk factors
Given rapid advancements in medical science, it is often challenging for the busy clinician to
remain up-to-date on the fundamental and multifaceted aspects of preventive cardiology and …
remain up-to-date on the fundamental and multifaceted aspects of preventive cardiology and …
Transforming growth factor-β signaling: from tissue fibrosis to therapeutic opportunities
LL Ren, XJ Li, TT Duan, ZH Li, JZ Yang… - Chemico-biological …, 2023 - Elsevier
Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …