Ketones and the heart: metabolic principles and therapeutic implications

TR Matsuura, P Puchalska, PA Crawford… - Circulation …, 2023 - Am Heart Assoc
The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …

[HTML][HTML] Investigating the link between ketogenic diet, NAFLD, mitochondria, and oxidative stress: a narrative review

A Paoli, G Cerullo - Antioxidants, 2023 - mdpi.com
Together with the global rise in obesity and metabolic syndrome, the prevalence of
individuals who suffer from nonalcoholic fatty liver disease (NAFLD) has risen dramatically …

[HTML][HTML] The ketogenic diet and neuroinflammation: the action of beta-hydroxybutyrate in a microglial cell line

R Polito, ME La Torre, F Moscatelli, G Cibelli… - International Journal of …, 2023 - mdpi.com
The ketogenic diet (KD), a diet high in fat and protein but low in carbohydrates, is gaining
much interest due to its positive effects, especially in neurodegenerative diseases. Beta …

[HTML][HTML] Ketone bodies and cardiovascular disease: an alternate fuel source to the rescue

AS Manolis, TA Manolis, AA Manolis - International Journal of Molecular …, 2023 - mdpi.com
The increased metabolic activity of the heart as a pump involves a high demand of
mitochondrial adenosine triphosphate (ATP) production for its mechanical and electrical …

Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC‐1α/SIRT3 Pathway to Prevent Western Diet‐Induced Obesity

YC Koh, SJ Lin, KY Hsu… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Sirtuin 1/peroxisome proliferator‐activated receptor gamma co‐activator 1 alpha
(SIRT1/PGC‐1α) pathway activation is known to promote thermogenesis and mitochondrial …

Effect of calorie restriction on redox status during chemically induced estropause in female mice

BM Ávila, BM Zanini, KP Luduvico, JD Hense… - Geroscience, 2024 - Springer
In females, there is a continuous decline of the ovarian reserve with age, which results in
menopause in women or estropause in mice. Loss of ovarian function results in metabolic …

[HTML][HTML] Molecular Mechanisms of Neuroprotection by Ketone Bodies and Ketogenic Diet in Cerebral Ischemia and Neurodegenerative Diseases

J Jang, SR Kim, JE Lee, S Lee, HJ Son… - International journal of …, 2023 - mdpi.com
Ketone bodies (KBs), such as acetoacetate and β-hydroxybutyrate, serve as crucial
alternative energy sources during glucose deficiency. KBs, generated through ketogenesis …

Intermittent fasting with ketogenic diet: A combination approach for management of chronic diseases

N Arora, S Pulimamidi, H Yadav, S Jain, J Glover… - Clinical Nutrition …, 2023 - Elsevier
Intermittent Fasting (IF) is the consumption of food and drinks within a defined time, while the
ketogenic diet (KD) switches the metabolism from glucose to fats. Continuation of intermittent …

[HTML][HTML] Ketogenic diet increases serum and white adipose tissue SIRT1 expression in mice

R Tozzi, F Campolo, E Baldini, MA Venneri… - International journal of …, 2022 - mdpi.com
Overnutrition and its sequelae have become a global concern due to the increasing
incidence of obesity and insulin resistance. A ketogenic diet (KD) is widely used as a dietary …

SIRT1 and ZNF350 as novel biomarkers for osteoporosis: A bioinformatics analysis and experimental validation

N Zhu, J Hou, J Si, N Yang, B Chen, X Wei… - Molecular Biology …, 2024 - Springer
Background Osteoporosis (OP) is characterized by bone mass decrease and bone tissue
microarchitectural deterioration in bone tissue. This study identified potential biomarkers for …