Inflammation in CNS neurodegenerative diseases

J Stephenson, E Nutma, P van der Valk, S Amor - Immunology, 2018 - Wiley Online Library
Neurodegenerative diseases, the leading cause of morbidity and disability, are gaining
increased attention as they impose a considerable socioeconomic impact, due in part to the …

Traumatic brain injury and risk of neurodegenerative disorder

BL Brett, RC Gardner, J Godbout, K Dams-O'Connor… - Biological …, 2022 - Elsevier
Traumatic brain injury (TBI), particularly of greater severity (ie, moderate to severe), has
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …

Severe traumatic brain injury: targeted management in the intensive care unit

N Stocchetti, M Carbonara, G Citerio, A Ercole… - The Lancet …, 2017 - thelancet.com
Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a
combined medical–surgical approach. Treatment aims to prevent additional brain damage …

Neuroinflammation and blood–brain barrier disruption following traumatic brain injury: pathophysiology and potential therapeutic targets

S Sulhan, KA Lyon, LA Shapiro… - Journal of neuroscience …, 2020 - Wiley Online Library
Abstract Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in
young adults and children in the developed world, occurring in over 1.7 million persons and …

A literature review of traumatic brain injury biomarkers

HS Ghaith, AA Nawar, MD Gabra… - Molecular …, 2022 - Springer
Research into TBI biomarkers has accelerated rapidly in the past decade owing to the
heterogeneous nature of TBI pathologies and management, which pose challenges to TBI …

Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury

A Chou, K Krukowski, T Jopson… - Proceedings of the …, 2017 - National Acad Sciences
Traumatic brain injury (TBI) is a leading cause of long-term neurological disability, yet the
mechanisms underlying the chronic cognitive deficits associated with TBI remain unknown …

An overview of management of intracranial hypertension in the intensive care unit

T Schizodimos, V Soulountsi, C Iasonidou… - Journal of …, 2020 - Springer
Intracranial hypertension (IH) is a clinical condition commonly encountered in the intensive
care unit, which requires immediate treatment. The maintenance of normal intracranial …

The immunological response to traumatic brain injury

EJ Needham, A Helmy, ER Zanier, JL Jones… - Journal of …, 2019 - Elsevier
Traumatic brain injury (TBI) is the leading cause of death and disability in young adults in the
developed world. The accuracy of early outcome-prediction remains poor even when all …

Molecular mechanisms underlying the beneficial effects of exercise on brain function and neurological disorders

K Nay, WJ Smiles, J Kaiser, LM McAloon, K Loh… - International Journal of …, 2021 - mdpi.com
As life expectancy has increased, particularly in developed countries, due to medical
advances and increased prosperity, age-related neurological diseases and mental health …

Lipid rafts as a therapeutic target: thematic review series: biology of lipid rafts

D Sviridov, N Mukhamedova, YI Miller - Journal of lipid research, 2020 - ASBMB
Lipid rafts regulate the initiation of cellular metabolic and signaling pathways by organizing
the pathway components in ordered microdomains on the cell surface. Cellular responses …