[HTML][HTML] Immunocal® limits gliosis in mouse models of repetitive mild-moderate traumatic brain injury

LA Koza, C Pena, M Russell, AC Smith, J Molnar… - Brain research, 2023 - Elsevier
Successive traumatic brain injuries (TBIs) exacerbate neuroinflammation and oxidative
stress. No therapeutics exist for populations at high risk of repetitive mild TBIs (rmTBIs). We …

[HTML][HTML] Inflammation following traumatic brain injury in humans: insights from data-driven and mechanistic models into survival and death

A Abboud, Q Mi, A Puccio, D Okonkwo… - Frontiers in …, 2016 - frontiersin.org
Inflammation induced by traumatic brain injury (TBI) is a complex mediator of morbidity and
mortality. We have previously demonstrated the utility of both data-driven and mechanistic …

Spectroscopic detection of traumatic brain injury severity and biochemistry from the retina

C Banbury, I Styles, N Eisenstein, ER Zanier… - Biomedical optics …, 2020 - opg.optica.org
Traumatic brain injury (TBI) is a major burden on healthcare services worldwide, where
scientific and clinical innovation is needed to provide better understanding of biochemical …

The emerging roles of circular RNAs in CNS injuries

X Qu, Z Li, J Chen, L Hou - Journal of neuroscience research, 2020 - Wiley Online Library
With high morbidity and mortality worldwide, injuries to the central nervous system (CNS)
usually result in devastating consequences. However, the underlying mechanisms have not …

[HTML][HTML] Dexamethasone-loaded hydrogels improve motor and cognitive functions in a rat mild traumatic brain injury model

C Macks, D Jeong, S Bae, K Webb, JS Lee - International Journal of …, 2022 - mdpi.com
Functional recovery following traumatic brain injury (TBI) is limited due to progressive
neuronal damage resulting from secondary injury-associated neuroinflammation. Steroidal …

Traumatic brain injury altered normal brain signaling pathways: implications for novel therapeutics approaches

A Rana, S Singh, R Sharma… - Current …, 2019 - ingentaconnect.com
Traumatic brain injury (TBI) is the main reason of lifelong disability and casualty worldwide.
In the United State alone, 1.7 million traumatic events occur yearly, out of which 50,000 …

Emerging Eye-Based Diagnostic Technologies for Traumatic Brain Injury

G Harris, JJS Rickard, G Butt, L Kelleher… - IEEE reviews in …, 2022 - ieeexplore.ieee.org
The study of ocular manifestations of neurodegenerative disorders, Oculomics, is a growing
field of investigation for early diagnostics, enabling structural and chemical biomarkers to be …

Withaferin A alleviates traumatic brain injury induced secondary brain injury via suppressing apoptosis in endothelia cells and modulating activation in the microglia

Z Zhou, W Xiang, Y Jiang, N Tian, Z Wei, X Wen… - European journal of …, 2020 - Elsevier
Traumatic brain injury (TBI) is a major public health concern with high rates of morbidity and
mortality worldwide. Currently used medications, though effective, are also associated with …

Temporal lobe contusions on computed tomography are associated with impaired 6-month functional recovery after mild traumatic brain injury: a TRACK-TBI study

JK Yue, EA Winkler, RC Puffer, H Deng… - Neurological …, 2018 - Taylor & Francis
Introduction: Mild traumatic brain injury (MTBI) can cause persistent functional deficits and
healthcare burden. Understanding the association between intracranial contusions and …

Impact of curcumin on traumatic brain injury and involved molecular signaling pathways

T Farkhondeh, S Samarghandian… - Recent patents on …, 2020 - ingentaconnect.com
Traumatic Brain Injury (TBI) is one of the main causes of mortality and morbidity worldwide
with no suitable treatment. The present study was designed to review the present literature …