Bacterial persisters: molecular mechanisms and therapeutic development

H Niu, J Gu, Y Zhang - Signal Transduction and Targeted Therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

Viable but non-culturable state formation and resuscitation of different antibiotic-resistant Escherichia coli induced by UV/chlorine

M Zhang, X Wang, X Deng, S Zheng, W Zhang, JZ He… - Water Research, 2024 - Elsevier
The presence of" viable but nonculturable"(VBNC) state and bacterial antibiotic resistance
(BAR) both pose significant threats to the safety of drinking water. However, limited data was …

The (p)ppGpp synthetase Rsh promotes rifampicin tolerant persister cell formation in Brucella abortus by regulating the type II toxin-antitoxin module mbcTA

X Liu, P Wang, N Yuan, Y Zhai, Y Yang, M Hao… - Frontiers in …, 2024 - frontiersin.org
Persister cells are transiently tolerant to antibiotics and are associated with recalcitrant
chronic infections due to recolonization of host cells after antibiotic removal. Brucella spp …

Salmonella Enteritidis antitoxin DinJ inhibits NLRP3-dependent canonical inflammasome activation in macrophages

D Gu, A Li, X Zang, T Huang, Y Guo, X Jiao… - Infection and …, 2024 - Am Soc Microbiol
The inflammasome is a pivotal component of the innate immune system, acting as a
multiprotein complex that plays an essential role in detecting and responding to microbial …

Contribution of the gyrA and waaG mutants to fluoroquinolones resistance, biofilm development, and persister cells formation in Salmonella enterica serovar Typhi

UF Khan, G Habib, H Gul, A Hayat, MU Rehman - Gene, 2024 - Elsevier
Fluoroquinolone resistance in Salmonella has been reported worldwide and poses a
serious public health threat in developing countries. Multiple factors contribute to …

Effect of Hormones and Biogenic Amines on Growth and Survival of Enterococcus durans

GI El'-Registan, OV Zemskova, OA Galuza… - Microbiology, 2023 - Springer
Lactic acid bacteria (LAB) are important components of the human microbiome. While they
are capable both of synthesis and response to the signals of the human humoral regulatory …

Role of VapBC4 toxin-antitoxin system of Sulfolobus acidocaldarius in heat stress adaptation

A Bhowmick, A Recalde, C Bhattacharyya, J Das… - bioRxiv, 2024 - biorxiv.org
Toxin-antitoxin (TA) systems are important for stress adaptation in prokaryotes, including
persistence, antibiotic resistance, pathogenicity, and biofilm formation. Toxins can cause cell …