[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
[HTML][HTML] Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies
Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
Cardiac ryanodine receptor calcium release deficiency syndrome
Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …
Cardiac alternans: from bedside to bench and back
Cardiac alternans arises from dynamical instabilities in the electrical and calcium cycling
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …
[HTML][HTML] Multi-scale computational modeling of spatial calcium handling from nanodomain to whole-heart: Overview and perspectives
Regulation of intracellular calcium is a critical component of cardiac electrophysiology and
excitation-contraction coupling. The calcium spark, the fundamental element of the …
excitation-contraction coupling. The calcium spark, the fundamental element of the …
[HTML][HTML] Electrophysiological mechanisms underlying T-wave alternans and their role in arrhythmogenesis
T-wave alternans (TWA) reflects every-other-beat alterations in the morphology of the
electrocardiogram ST segment or T wave in the setting of a constant heart rate, hence, in the …
electrocardiogram ST segment or T wave in the setting of a constant heart rate, hence, in the …
[HTML][HTML] Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation–remodeled hearts
T Liu, F Xiong, XY Qi, J Xiao, L Villeneuve, I Abu-Taha… - JCI insight, 2020 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) alters atrial cardiomyocyte (ACM) Ca 2+ handling, promoting ectopic
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …
Ca2+-CaM Dependent Inactivation of RyR2 Underlies Ca2+ Alternans in Intact Heart
Rationale: Ca2+ alternans plays an essential role in cardiac alternans that can lead to
ventricular fibrillation, but the mechanism underlying Ca2+ alternans remains undefined …
ventricular fibrillation, but the mechanism underlying Ca2+ alternans remains undefined …
[HTML][HTML] Role of Reduced Sarco-Endoplasmic Reticulum Ca2+-ATPase Function on Sarcoplasmic Reticulum Ca2+ Alternans in the Intact Rabbit Heart
Sarcoplasmic reticulum (SR) Ca2+ cycling is tightly regulated by ryanodine receptor (RyR)
Ca2+ release and sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) Ca2+ uptake …
Ca2+ release and sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) Ca2+ uptake …
[HTML][HTML] The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2+-ATPase, is a major determinant of Ca2+ alternans in intact mouse hearts
Sarcoplasmic reticulum (SR) Ca 2+ cycling is governed by the cardiac ryanodine receptor
(RyR2) and SR Ca 2+-ATPase (SERCA2a). Abnormal SR Ca 2+ cycling is thought to be the …
(RyR2) and SR Ca 2+-ATPase (SERCA2a). Abnormal SR Ca 2+ cycling is thought to be the …