Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …

Erythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane
receptor protein which is a part of the most prominent family of receptor tyrosine kinases …

The study of protein-drug interaction plays a crucial role in understanding drug mechanisms,
identifying new drug targets and biomarkers, and facilitating drug development and disease …

The scarcity and dynamic nature of phosphotyrosine (pTyr)-modified proteins pose a
challenge for researching protein complexes with pTyr modification, which are assembled …

Colorectal cancer (CRC), a common malignant tumour of the gastrointestinal tract, is a life-
threatening cancer worldwide. Mutations in KRAS and BRAF, the major driver mutation …

The kinome includes over 500 different protein kinases, which form an integrated kinase
network that regulates cellular phosphorylation signals. The kinome plays a central role in …

Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes
during development and throughout adulthood. This versatility is likely facilitated by the …

Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes
during development and throughout adulthood. This versatility is likely facilitated by the …

The family of Eph receptor tyrosine kinases and their Ephrin ligands system constitutes a
bidirectional signaling pathway. Eph/Ephrin system coordinate a wide spectrum of …

Organ formation and homeostasis require the coordination of cell-cell adhesion, epithelial
cell polarity and orientation of cell division to organize epithelial tissue architecture. We have …