Eph receptors and ephrins in cancer progression
EB Pasquale - Nature Reviews Cancer, 2024 - nature.com
Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …
make up the 'Eph system') in cancer development and progression has been accumulating …
Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Erythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane
receptor protein which is a part of the most prominent family of receptor tyrosine kinases …
receptor protein which is a part of the most prominent family of receptor tyrosine kinases …
Emerging affinity methods for protein-drug interaction analysis
X Zheng, H Zhu, X Zhao, J Wang, Q Li… - Journal of Pharmaceutical …, 2024 - Elsevier
The study of protein-drug interaction plays a crucial role in understanding drug mechanisms,
identifying new drug targets and biomarkers, and facilitating drug development and disease …
identifying new drug targets and biomarkers, and facilitating drug development and disease …
Integrated Platform for Large-Scale Quantitative Profiling of Phosphotyrosine Signaling Complexes Based on Cofractionation/Mass Spectrometry and Complex …
W Liu, X Wang, H Yu, G Yan, S Shen, M Gao… - Analytical …, 2024 - ACS Publications
The scarcity and dynamic nature of phosphotyrosine (pTyr)-modified proteins pose a
challenge for researching protein complexes with pTyr modification, which are assembled …
challenge for researching protein complexes with pTyr modification, which are assembled …
Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS …
D Gunji, R Narumi, S Muraoka, J Isoyama… - Molecular …, 2023 - pubs.rsc.org
Colorectal cancer (CRC), a common malignant tumour of the gastrointestinal tract, is a life-
threatening cancer worldwide. Mutations in KRAS and BRAF, the major driver mutation …
threatening cancer worldwide. Mutations in KRAS and BRAF, the major driver mutation …
Mapping the Protein Kinome: Current Strategy and Future Direction
Z Hou, H Liu - Cells, 2023 - mdpi.com
The kinome includes over 500 different protein kinases, which form an integrated kinase
network that regulates cellular phosphorylation signals. The kinome plays a central role in …
network that regulates cellular phosphorylation signals. The kinome plays a central role in …
Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
C Chang, SL Banerjee, SS Park, XL Zhang… - Elife, 2024 - elifesciences.org
Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes
during development and throughout adulthood. This versatility is likely facilitated by the …
during development and throughout adulthood. This versatility is likely facilitated by the …
[HTML][HTML] Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
C Chang, SL Banerjee, SS Park, X Zhang… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes
during development and throughout adulthood. This versatility is likely facilitated by the …
during development and throughout adulthood. This versatility is likely facilitated by the …
[HTML][HTML] The Eph/Ephrin system in primary bone tumor and bone cancer pain
L Wang, W Li, Y Pan - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
The family of Eph receptor tyrosine kinases and their Ephrin ligands system constitutes a
bidirectional signaling pathway. Eph/Ephrin system coordinate a wide spectrum of …
bidirectional signaling pathway. Eph/Ephrin system coordinate a wide spectrum of …
EPHA1 and EPHB4 tyrosine kinase receptors regulate epithelial morphogenesis
N Lavoie, A Scribe, FJM Chartier, K Ghani, A Jette… - bioRxiv, 2024 - biorxiv.org
Organ formation and homeostasis require the coordination of cell-cell adhesion, epithelial
cell polarity and orientation of cell division to organize epithelial tissue architecture. We have …
cell polarity and orientation of cell division to organize epithelial tissue architecture. We have …