''It seems more than ever likely that blood-derived stem tive capacity. 47-49 In the allogeneic
setting, mobilized blood cells have also been used instead of BM. 50 Umbilical cord cells …

Publisher Summary This chapter focuses on the importance of stem cell factor (SCF) and the
stem cell factor receptor (SCFR) in hematopoiesis and other complex developmental …

Interaction of hemopoietic cells with the elements of the underlying bone marrow stroma, the
unique site of their" homing" in adult individuals, is essential for sustained normal …

Thrombopoietin (TPO), the ligand for the receptor protooncogene c-mpl, has been cloned
and shown to be the critical regulator of platelet production. Several features of c-Mpl …

Steel factor (SLF) is a recently identified growth factor which is the gene product of the
murine Steel locus and a ligand for the c-kit tyrosine kinase receptor, the product of the …

The c-kit proto-oncogen (CD117) has been shown to be present in several cell types
including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 …

Human cord blood was used as a source of progenitor and stem cells to evaluate the effect
of recombinant human stem-cell factor (SCF) on colony formation and the generation of …

Despite extensive research on the molecular mechanisms of signal transduction by growth
factors and their oncogenic receptor tyrosine kinases, the physiological relevance of these …

Human stem cell factor (SCF) acts in the presence of other growth factors to stimulate the
growth of primitive hematopoietic progenitor cells. These effects are performed by activation …

We analyzed the radioprotective effects of gamma-tocotrienol (GT3) on hematopoietic stem
cells (HSCs) and progenitor cells (HPCs) in sublethally irradiated mice. Flow cytometry …